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Merck
CN

MABS2439

Anti-Adiponectin Antibody, clone AD72

别名:

30 kDa adipocyte complement-related protein, Adipocyte complement-related 30 kDa protein (ACRP30), Adipocyte, C1q and collagen domain-containing protein, Adipose most abundant gene transcript 1 protein, apM-1, Gelatin-binding protein, ACDC, ACRP30, APM1,

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
Conjugate:
unconjugated
Clone:
AD72, monoclonal
Application:
ELISA
Citations:
-
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biological source

mouse

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

AD72, monoclonal

mol wt

calculated mol wt 26.41 kDa, observed mol wt ~N/A kDa

purified by

using protein G

species reactivity

human

packaging

antibody small pack of 100

technique(s)

ELISA: suitable

isotype

IgG2aκ

epitope sequence

Unknown

Protein ID accession no.

UniProt accession no.

storage temp.

2-8°C

target post-translational modification

unmodified

Quality Level

Gene Information

human ... ADIPOQ(9370)

General description

Adiponectin (UniProt: Q15848; also known as 30 kDa adipocyte complement-related protein, Adipocyte complement-related 30 kDa protein (ACRP30), Adipocyte, C1q and collagen domain-containing protein, Adipose most abundant gene transcript 1 protein, apM-1, Gelatin-binding protein) is encoded by the ADIPOQ (also known as ACDC, ACRP30, APM1, GBP28) gene (Gene ID: 9370) in human. Adiponectin is a homomultimeric secreted glycoprotein, characterized by a collagen-like domain (aa 42-107) and a globular, C1q domain (aa 108-244). It exists in several oligomeric forms, including trimers (low-molecular-weight (LMW)), hexamers, and 12 to 18-mers (high-molecular-weight (HMW)) complexes, with the HMW form being the most biologically active. Adiponectin enhances insulin sensitivity, regulate glucose metabolism, and promote fatty acid oxidation. It activates various signaling pathways, notably the AMP-activated protein kinase (AMPK) pathway, leading to improved metabolic health. Additionally, adiponectin has anti-inflammatory effects and plays a role in cardiovascular health. Adiponectin is expressed in adipose tissue and secreted into the bloodstream. Low levels of adiponectin are linked to obesity, type 2 diabetes, and cardiovascular diseases. Its anti-inflammatory properties suggest a protective role against atherosclerosis and other inflammatory conditions.

Immunogen

hFc-tagged, full length, human recombinant Adiponectin.

Application

Quality Control Testing

Evaluated by ELISA with hFc-tagged, full length, human recombinant Adiponectin.


Enzyme Immunoassay (ELISA): Various dilutions from a representative lot of this antibody detected hFc- tagged, recombinant human Adiponectin in ELISA application.

Biochem/physiol Actions

Clone AD72 is a mouse recombinant monoclonal antibody that detects Adiponectin. Suitable for ELISA application paired with Anti-Adiponectin, clone AD105 (MABS2438).

Physical form

Purified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Preparation Note

0.5 mg/mL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
Recommended storage: +2°C to +8°C.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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