MABS62
抗-GREB1抗体，克隆GREB1Ab
clone GREB1Ab, from mouse
别名:
growth regulation by estrogen in breast cancer 1, Gene regulated in breast cancer 1 protein, protein GREB1, gene regulated by estrogen in breast cancer protein
产品名称
抗-GREB1抗体，克隆GREB1Ab, clone GREB1Ab, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
GREB1Ab, monoclonal
species reactivity
human
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GREB1(9687)
Analysis Note
对照
MCF-7细胞裂解液
MCF-7细胞裂解液
通过蛋白质印迹法在MCF-7细胞裂解液中进行评估。
蛋白质印迹分析：0.5 µg/mL该抗体在10 µg MCF-7细胞裂解液中检测到GREB1。
蛋白质印迹分析：0.5 µg/mL该抗体在10 µg MCF-7细胞裂解液中检测到GREB1。
Application
免疫组化分析： 先前批次的1:600稀释液在前列腺组织中检测到GREB1。
免疫细胞化学分析： 先前批次已在一个独立实验室中进行了IP测试。（Hnatyszyn, H., et al. 2009）。Breast Cancer Res Treat
DOI 10.1007/s10549-009-0584-x.)
免疫细胞化学分析： 先前批次已在一个独立实验室中进行了IP测试。（Hnatyszyn, H., et al. 2009）。Breast Cancer Res Treat
DOI 10.1007/s10549-009-0584-x.)
研究子类别
激素 & 受体
激素 & 受体
研究类别
信号传导
凋亡 & 癌症
信号传导
凋亡 & 癌症
该抗-GREB1抗体克隆GREB1Ab经验证可用于WB、IH、IC中GREB1的检测。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
GREB1，也称乳腺癌蛋白1调控基因，被证明与乳腺癌细胞的增殖有关，受雌激素控制。GREB1有潜力成为内分泌治疗应答的临床标志物和治疗靶点。GREB1也可能是前列腺癌的调节因子。
观测分子量〜216 kDa。 在某些裂解物中可能观察到未表征的条带。
Immunogen
对应于人GREB1的重组蛋白。
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
形式：纯化
纯化的小鼠单克隆IgG1κ，溶于含0.1 M Tris-甘氨酸（pH 7.4），150 mM NaCl和0.05％叠氮化钠的缓冲液中。
蛋白G
Preparation Note
自收到之日起，在2-8°C条件下可稳定保存1年。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Yanming Wu et al.
Cancer research, 78(3), 671-684 (2017-12-08)
Resistance to cancer treatment can be driven by epigenetic reprogramming of specific transcriptomes in favor of the refractory phenotypes. Here we discover that tamoxifen resistance in breast cancer is driven by a regulatory axis consisting of a master transcription factor
Hai-Feng Zhang et al.
Science advances, 9(34), eadg6693-eadg6693 (2023-08-23)
MYCN amplification (MNA) is a defining feature of high-risk neuroblastoma (NB) and predicts poor prognosis. However, whether genes within or in close proximity to the MYCN amplicon also contribute to MNA+ NB remains poorly understood. Here, we identify that GREB1
Eun Myoung Shin et al.
Science advances, 7(12) (2021-03-19)
What covalent modifications control the temporal ubiquitination of ERα and hence the duration of its transcriptional activity remain poorly understood. We show that GREB1, an ERα-inducible enzyme, catalyzes O-GlcNAcylation of ERα at residues T553/S554, which stabilizes ERα protein by inhibiting
GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling.
Shinji Matsumoto et al.
Nature communications, 10(1), 3882-3882 (2019-08-30)
The β-catenin mutation is frequently observed in hepatoblastoma (HB), but the underlying mechanism by which Wnt/β-catenin signaling induces HB tumor formation is unknown. Here we show that expression of growth regulation by estrogen in breast cancer 1 (GREB1) depends on
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