MABT100
Anti-Girdin Antibody, CT, clone 10E6.1
clone 10E6.1, from mouse
别名:
Girdin, Akt phosphorylation enhancer, Coiled-coil domain-containing protein 88A, G alpha-interacting vesicle-associated protein, GIV, Girders of actin filament, Hook-related protein 1, HkRP1
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
10E6.1, monoclonal
Application:
ICC, IHC, IP, WB
Citations:
3
biological source
mouse
Quality Segment
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
10E6.1, monoclonal
species reactivity
human
technique(s)
immunocytochemistry: suitable, immunohistochemistry: suitable (paraffin), immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... CCDC88A(55704)
General description
Girdin (Ccdc88a; APE, GIV, or HkRP1) is a ubiquitous protein belonging to the CCDC88 family. Girdin is an actin-binding protein which interacts with actin via its C-terminal domain, and may play a crucial role in cell motility and cytoskeleton remodeling. These effects may be regulated by a reciprocal relationship between Girdin and Akt. Akt phosphorylates Girdin, and Girdin binds to Akt and enhances phosphorylation of Akt, thereby promoting phosphorylation of Akt’s downstream targets such as GSK-3β and FOXO1A. Girdin/Akt signaling may play an important role in cancer by facilitating the proliferation of cancer cells.
~216 kDa observed
Immunogen
Recombinant protein corresponding to human Girdin.
Application
Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Girdin in epithelial cells of human prostate tissue.
Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected Girdin in HeLa cells.
Immunoprecipitation Analysis: A representative lot immunoprecipitated Girdin in COS-7 cell lysate.
Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected Girdin in HeLa cells.
Immunoprecipitation Analysis: A representative lot immunoprecipitated Girdin in COS-7 cell lysate.
This Anti-Girdin, C-terminus Antibody, clone 10E6.1 is validated for use in Western Blotting, IHC(P), ICC, Immunoprecipitation for the detection of Girdin, C-terminus, clone 10E6.1.
Physical form
Format: Purified
Analysis Note
Evaluated by Western Blot in human brain tissue lysate.
Wesetern Blot Analysis: A 1:5000 dilution of this antibody detected Girdin in 10 µg of human brain tissue lysate.
Wesetern Blot Analysis: A 1:5000 dilution of this antibody detected Girdin in 10 µg of human brain tissue lysate.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable