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Merck
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RMHMAG-84K

MILLIPLEX® 大鼠代谢激素磁珠面板-代谢多重检测

The analytes available for this multiplex kit are: Amylin (Active), C-Peptide 2, Ghrelin (Active), GIP (Total), GLP-1 (Active), Glucagon, IL-6, Insulin, Leptin, MCP-1, PP, PYY, TNF-α.

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关于此项目

UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000

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species reactivity

rat

manufacturer/tradename

Milliplex®

assay range

accuracy: 103%
(Amylin (Active)), accuracy: 96%
(GLP-1 (Active)), accuracy: 96%
(IL-6), accuracy: 96%
(MCP-1), accuracy: 98%
(TNFα), accuracy: 99%
(C-Peptide 2), accuracy: 99%
(Insulin), sensitivity: 1-62 pg/mL, standard curve range: 14-10,000 pg/mL
(Glucagon & TNFα), standard curve range: 2.7-2,000 pg/mL
(GIP (Total)), standard curve range: 41-30,000 pg/mL
(Amylin (Active) & GLP-1 (Active)), standard curve range: 69-50,000 pg/mL
(C-Peptide 2, IL-6, Insulin, Leptin & MCP-1), standard curve range: 7-5,000 pg/mL
(Ghrelin (Active), PP & PYY (Total))

technique(s)

multiplexing: suitable

detection method

fluorometric (Luminex xMAP)

shipped in

wet ice

Quality Level

200

General description

代谢综合症是一系列疾病，包括血压升高，胰岛素水平升高，胆固醇水平异常和腰部脂肪过多。代谢综合征的关键特征包括胰岛素抗性，葡萄糖耐受不良，高血压，血脂异常和中枢性肥胖。

MILLIPLEX® 大鼠代谢面板是一种13重试剂盒，用于同时定量组织/细胞裂解物和培养上清液样品以及血清或血浆样品中的以下任何或所有分析物：Amylin（活性），C肽2，活性胃饥饿素，GIP，GLP-1，胰高血糖素，IL-6，胰岛素，瘦素，MCP-1，PP，PYY和TNFα。该试剂盒采用96孔板，包含冻干标准混合物、两个内部检测质控品，最多可测量38份样本，一式两份。

Luminex® xMAP®平台使用磁珠免疫分析格式，以实现理想的速度和灵敏度，同时定量多种分析物，从而显著提高生产力，同时节省有价值的样品量。

面板类型：代谢

Application

  • 分析物：Amylin（活性），C肽2，胃饥饿素（活性），GIP（总计），GLP-1（活性），胰高血糖素，IL-6，胰岛素，瘦素，MCP-1（CCL2），胰多肽（PP），PYY（总计）和TNFα
  • 推荐的样品类型：大鼠血清、血浆、细胞/组织培养物上清液和裂解物。
  • 注：对于特定的分析物，应在采血后添加蛋白酶抑制剂：GLP-1的DPPIV（活性）；胰岛淀粉样多肽蛋白酶抑制剂混合物（活性）；胰高血糖素用抑肽酶；胃饥饿素的丝氨酸蛋白酶抑制剂（活性）
  • 建议的样品稀释度：每孔25 μL未稀释的血清或血浆；细胞/组织培养样品可能需要在适当的对照培养基中稀释。
  • 分析运行时间：在2-8℃下过夜（18-20小时）
  • 研究类别：代谢
  • 研究类别：代谢紊乱、肥胖、内分泌

Biochem/physiol Actions

交叉反应性
与其他测试的激素无明显交叉反应。

Features and Benefits

通过在此面板中选择可用的分析物来设计多重试剂盒。

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

法规信息

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Atanu Pal et al.
Diabetes, 64(6), 1941-1950 (2015-01-13)
The antidiabetes effects of Roux-en-Y gastric bypass (RYGB) are well-known, but the underlying mechanisms remain unclear. Isolating the proximal small intestine, and in particular its luminal glucose sensors, from the nutrient stream has been proposed as a critical change, but
Carolina Soares Moura et al.
Food & nutrition research, 61(1), 1290740-1290740 (2017-03-23)
Background: Several physiologically beneficial effects of consuming a whey protein hydrolysate (WPH) have been attributed to the greater availability of bioactive peptides. Aims: The aim was to investigate the effect of four branched-chain amino acid- (BCAA-)containing dipeptides, present in WPH
Starr Villavasso et al.
Nutrients, 11(11) (2019-11-14)
We have previously shown that 6 weeks of intermittent high-fat diet (Int-HFD) pre-exposure significantly reduced alcohol drinking in rats, providing preliminary evidence of the effectiveness of a dietary intervention in reducing alcohol intake. However, the functional framework and underlying neurobiological
Jean-Baptiste Cavin et al.
Gastroenterology, 150(2), 454-464 (2015-10-21)
Bariatric procedures, such as Roux-en-Y gastric bypass (RYGB) or vertical sleeve gastrectomy (VSG), are the most effective approaches to resolve type 2 diabetes in obese individuals. Alimentary glucose absorption and intestinal disposal of blood glucose have not been directly compared
Alexander A Moghadam et al.
Experimental biology and medicine (Maywood, N.J.), 242(18), 1786-1794 (2017-12-02)
Alterations in gut hormone signaling are a likely contributing factor to the metabolic disturbances associated with overweight/obesity as they coordinate the timing of feeding behavior, absorption, and utilization of nutrients. These hormones are released in response to food intake, or
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Quality Control Range Sheet- RMH-110 and RMH-210
The Power of Biomarker Analysis
96 well Template Single
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