生物来源
rabbit
质量水平
抗体形式
serum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
liquid
不包含
preservative
种属反应性
rat, mouse, human
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
dilution
(Immunoblotting (1:2500)
Immunocytochemistry (1:2500)
Immunoprecipitation (1:250))
同位素/亚型
IgG
运输
wet ice
储存温度
2-8°C
靶向翻译后修饰
unmodified
基因信息
human ... TRIB3(57761)
一般描述
Rabbit polyclonal antibdy supplied as undiluted serum that has been adsorbed against GST to remove GST-reactive antibodies. Recognizes the ~45 kDa TRB3 protein.
Recognizes the ~45 kDa TRB3 protein in HepG2 cells.
TRB3 is a protein that is reported to disrupt insulin signaling by binding directly to Akt and blocking activation of the kinase.
This Anti-TRB3 (1-145) Rabbit pAb is validated for use in Immunoblotting, Immunocytochemistry, Immunoprecipitation for the detection of TRB3 (1-145).
免疫原
Mouse
a recombinant protein consisting of amino acids 1-145 of mouse TRB3, fused to GST
应用
Immunoblotting (1:2500)
Immunocytochemistry (1:2500)
Immunoprecipitation (1:250)
Immunocytochemistry (1:2500)
Immunoprecipitation (1:250)
外形
Undiluted serum.
制备说明
For long-term storage aliquot and freeze (-20°C). Avoid freeze/thaw cycles.
分析说明
Positive Control
HepG2 cells
HepG2 cells
其他说明
Antibody should be titrated for optimal results in individual systems.
Du, K., et al. 2003. Science300, 1574.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Wei Luo et al.
Frontiers in physiology, 12, 637432-637432 (2021-06-29)
Eccentric exercise training accompanied by a low-fat diet can prevent insulin resistance (IR) and is currently an effective method for the treatment of IR induced by high-fat diet (HFD)-associated obesity. However, the molecular mechanisms underlying this improvement of IR in
N Zareen et al.
Cell death and differentiation, 20(12), 1719-1730 (2013-11-12)
The mechanisms governing neuron death following NGF deprivation are incompletely understood. Here, we show that Trib3, a protein induced by NGF withdrawal, has a key role in such death via a loop involving the survival kinase Akt and FoxO transcription
Ran Hee Choi et al.
Biochemical and biophysical research communications, 493(3), 1236-1242 (2017-10-01)
Skeletal muscle atrophy is associated with a disruption in protein turnover involving increased protein degradation and suppressed protein synthesis. Although it has been well studied that the IGF-1/PI3K/Akt pathway plays an essential role in the regulation of the protein turnover
Bevin C English et al.
PLoS pathogens, 13(9), e1006589-e1006589 (2017-09-28)
The ability of intracellular pathogens to manipulate host-cell viability is critical to successful infection. Some pathogens promote host-cell survival to protect their replicative niche, whereas others trigger host-cell death to facilitate release and dissemination of the pathogen after intracellular replication
Pascaline Aimé et al.
Neurobiology of disease, 136, 104725-104725 (2020-01-09)
Identifying disease-causing pathways and drugs that target them in Parkinson's disease (PD) has remained challenging. We uncovered a PD-relevant pathway in which the stress-regulated heterodimeric transcription complex CHOP/ATF4 induces the neuron prodeath protein Trib3 that in turn depletes the neuronal
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