biological source
bovine plasma
form
suspension
specific activity
≥2 units/mg protein (At 25 °C with Chromozym PL as the substrate.)
mol wt
Mr ~85 kDa
packaging
pkg of 1 mL (5 U)
manufacturer/tradename
Roche
optimum pH
8.9
shipped in
wet ice
storage temp.
2-8°C
General description
纤维蛋白溶酶来源于其前体纤维蛋白溶酶原的蛋白质水解性裂解。人纤维蛋白溶酶包含两条多肽链。多肽链通过二硫桥相连。
Application
牛纤维蛋白溶酶已被用作评估纤维蛋白溶酶传感器和蛋白水解检测的标准品。
Biochem/physiol Actions
丝氨酸内肽酶，水解赖氨酸或精氨酸羧基侧的肽键和酯键；比胰蛋白酶的选择性更高。
它在蛋白酶解和纤维蛋白溶解起着重要作用。纤维蛋白溶酶具有导致发炎的活性。纤维蛋白溶酶也涉及肽键的水解，之后产生精氨酸或赖氨酸。它还可以裂解激素，如胰高血糖素、促血小板生成素和生长激素。纤维蛋白溶酶在C3和C5等补体因子、凝血因子V和VII、基质蛋白、生长因子、上皮细胞钙粘蛋白和金属蛋白酶的裂解中起一定作用。
Physical form
悬浮于 3.2M 硫酸铵溶液中
Other Notes
仅用于生命科学研究。不可用于诊断。
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
does not flash
flash_point_c
does not flash
法规信息
低风险生物材料
此项目有
Chunyue Zhang et al.
Journal of dairy science, 103(1), 179-190 (2019-11-18)
Fat separation is a limiting factor for the shelf life of UHT milk. It may be promoted by the proteolysis of fat surface-adsorbed proteins (FSAP) by proteases that remain active after UHT treatment. The aim of this research was to
Primary structure of the B-chain of human plasmin
WIMAN B.
European Journal of Biochemistry, 76(1), 129-137 (1977)
A rapid and sensitive biosensor for measuring plasmin activity in milk
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Sensors and Actuators B, Chemical, 301, 127141-127141 (2019)
Plasmin-induced proteolysis and the role of apoprotein (a), lysine and synthetic lysine analogs
Rath M and Pauling L
Journal of Orthomolecular Medicine, 7(1), 17-23 (1992)
Plasmin as a proinflammatory cell activator
Syrovets T, et al.
Journal of Leukocyte Biology, 92(3), 509-519 (2012)
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