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经验公式（希尔记法）:
C16H24N2O4 · HCl
化学文摘社编号:
分子量:
344.83
PubChem Substance ID:
UNSPSC Code:
12352204
Beilstein/REAXYS Number:
4628066
MDL number:
description
[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-L-leucine hydrochloride
assay
95% (HPLC)
form
crystalline powder
packaging
pkg of 10 mg
manufacturer/tradename
Roche
storage condition
protect from light
technique(s)
protein purification: suitable
mp
195-205 °C
solubility
water: soluble 25 g/L, alcohol: soluble 5 g/L
λmax
255-260 nm at 1 N in hydrochloric acid
shipped in
wet ice
storage temp.
2-8°C
SMILES string
O=C(N[C@@H](CC(C)C)C(O)=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1.Cl[H]
InChI
1S/C16H24N2O4.ClH/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11;/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22);1H/t12-,13+,14+;/m1./s1
InChI key
XGDFITZJGKUSDK-UDYGKFQRSA-N
Application
Bestatin has been used as a protease inhibitor for the purification of his-tagged Tau protein.
Biochem/physiol Actions
Bestatin exhibits anti-angiogenic property and inhibits new blood vessel formation at the early stage of tumor growth and in the metastatic sites.
一种氨肽酶选择性金属蛋白酶抑制剂。苯丁抑制素是亮氨酸氨基肽酶、氨基肽酶 B 和三氨基肽酶的竞争性和特异性抑制剂。在 60 nM 抑制氨肽酶 B（用精氨酸-β-萘胺为底物）和亮氨酸氨基肽酶在 20 nM（亮氨酸-β-萘胺为底物）。其显示对氨肽酶 A、胰蛋白酶、糜蛋白酶、弹性蛋白酶、木瓜蛋白酶、胃蛋白酶或溶血素无抑制作用。它有希望成为一种新型镇痛药，因为它能保护内源性阿片肽免受降解。
Preparation Note
Working concentration: 40 μg/ml (130 μM)
Working solution: Recommended solvents are 1 M HCl, methanol or 0.15 M NaCl.
Soluble to 20 mg/ml in 1 M HCl, 5 mg/ml in methanol, and 1 mg/ml in 0.15 M NaCl. Do not store in HCl.
For best results, use a stock solution of 2–5 mg/ml in methanol.
Storage conditions (working solution): -15 to -25 °C
Avoid repeated freezing!
Working solution: Recommended solvents are 1 M HCl, methanol or 0.15 M NaCl.
Soluble to 20 mg/ml in 1 M HCl, 5 mg/ml in methanol, and 1 mg/ml in 0.15 M NaCl. Do not store in HCl.
For best results, use a stock solution of 2–5 mg/ml in methanol.
Storage conditions (working solution): -15 to -25 °C
Avoid repeated freezing!
Soluble to 20 mg/ml in 1 M HCl, 5 mg/ml in methanol, and 1 mg/ml in 0.15 M NaCl. Do not store in HCl. Roche recommends preparing a stock solution of 2 to 5 mg/ml in methanol.
Solutions are stable for 6 months when stored in aliquots at -15 to -25 °C.
Solutions are stable for 6 months when stored in aliquots at -15 to -25 °C.
Store at 2 to 8 °C. (Store dry!)
Other Notes
仅用于生命科学研究。不可用于诊断。
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
Anti-tumor angiogenesis effect of aminopeptidase inhibitor bestatin against B16-BL6 melanoma cells orthotopically implanted into syngeneic mice.
Aozuka Y, et al.
Cancer letters, 216(1), 35-42 (2004)
Production of recombinant tau oligomers in vitro.
Methods in Cell Biology, 141, 45-64 (2017)
G Mathé
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 45(2-3), 49-54 (1991-01-01)
Bestatin, the dipeptide N-((2S, 3R)-3-amino-2-hydroxy-4-phenyl butanyl) L-leucine is a leucine aminopeptidase and aminopeptidase-B inhibitor. It exerts a direct stimulating effect on lymphocytes (and monocytes) via its fixation on cell surface leucine-aminopeptidase, and an indirect effect on monocytes (and lymphocytes) via