产品名称
ATP-γ-S, =90% (HPLC), solution, pkg of 200 μL (20 μmol)
description
C10H16N5O12P3SLi (Formula)
Lithium salt
assay
90% (HPLC)
form
solution
mol wt
523.2
packaging
pkg of 200 μL (20 μmol)
manufacturer/tradename
Roche
λmax
260 nm at 100 mmol/L
shipped in
dry ice
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
腺苷5′-O-(3-硫代三磷酸)(ATP-γ-S)是ATP依赖性酶系统的底物和抑制剂。可被磷酸酶和大多数ATP酶缓慢水解。硫代磷酸化后的蛋白可抗蛋白磷酸酶作用。ATP-γ-S可作为损伤相关分子模式分子(DAMP)和NLR家族热蛋白结构域相关蛋白3(NLRP3)炎性小体激活剂。作为APT类似物，ATP-γ-S可用作真核细胞翻译起始因子-4A(eIF4A)催化RNA诱导核苷酸水解和RNA解旋活动的底物。
General description
腺苷 5′-O-（3-硫代三磷酸盐），锂盐，溶液。
Other Notes
仅用于生命科学研究。不可用于诊断。
Analysis Note
污染物：≤10% ADP (HPLC)
Application
ATP-γ-S用途：
- 用于处理THP-1巨噬细胞株，以检测内质网(ER)应激是否会导致白介素(IL)-1β生成
- 用于质谱法酰胺氢交换(amide hydrogen exchange, HX)实验，研究cyclomarin A(CymA)诱导的NMtb-ClpC结构变化
- 作为CMG结合缓冲液添加剂，用于凝胶法DNA解旋实验
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
No data available
flash_point_c
No data available
Alana G Lerner et al.
Cell metabolism, 16(2), 250-264 (2012-08-14)
When unfolded proteins accumulate to irremediably high levels within the endoplasmic reticulum (ER), intracellular signaling pathways called the unfolded protein response (UPR) become hyperactivated to cause programmed cell death. We discovered that thioredoxin-interacting protein (TXNIP) is a critical node in this "terminal UPR."
Michael Maurer et al.
Cell chemical biology, 26(8), 1169-1179 (2019-06-18)
ATP-driven bacterial AAA+ proteases have been recognized as drug targets. They possess an AAA+ protein (e.g., ClpC), which threads substrate proteins into an associated peptidase (e.g., ClpP). ATPase activity and substrate selection of AAA+ proteins are regulated by adapter proteins
Antonia Recabal et al.
Journal of neurochemistry, 156(2), 182-199 (2020-09-17)
In the adult hypothalamus, the neuronal precursor role is attributed to the radial glia-like cells that line the third-ventricle (3V) wall called tanycytes. Under nutritional cues, including hypercaloric diets, tanycytes proliferate and differentiate into mature neurons that moderate body weight
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持