grade
purum
assay
≥95.0% (CHN)
mp
192-196 °C (lit.)
SMILES string
CC(=O)Nc1ccc-2c(Cc3ccccc-23)c1
InChI
1S/C15H13NO/c1-10(17)16-13-6-7-15-12(9-13)8-11-4-2-3-5-14(11)15/h2-7,9H,8H2,1H3,(H,16,17)
InChI key
CZIHNRWJTSTCEX-UHFFFAOYSA-N
Application
N-(2-fluorenyl)acetamide is a hepatic carcinogen whose principle target protein is the liver fatty acid binding protein (L-FABP). N-(2-Fluorenyl)acetamide has been used in a study to establish a hepatoma model to study the dynamic expression and quantitative analysis of hepatic nuclear factor-kappa B and its gene during the development of hepatocellular carcinoma.
Biochem/physiol Actions
一种遗传毒性致癌物，用于诱发大鼠肝癌模型。当因肝脏中的细胞色素 CYP1A2 发生 N-羟基化时，2-AAF 与 DNA 形成加合物，在肝脏和膀胱中发生肿瘤。
法规信息
新产品
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S H Khan et al.
Proceedings of the National Academy of Sciences of the United States of America, 87(23), 9401-9405 (1990-12-01)
Liver fatty acid binding protein (L-FABP) is the principal target protein of the hepatic carcinogen N-(2-fluorenyl)acetamide (2-acetylaminofluorene) in rat liver. In addition, the cyclopentenone prostaglandins (PG), PGA, PGJ2, and delta 12-PGJ2, inhibit the growth of many cell types in vitro.
Zhi-Zhen Dong et al.
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 16(9), 669-673 (2008-09-30)
To investigate the kinetic expression and alteration of nuclear transcription factor-kappa B (NF-kappaB) and its gene in hepatocellular carcinoma (HCC) development. A hepatoma model was established with N-(2-fluorenyl) acetamide (2-FAA) using male SD rats. Morphological changes and dynamic alterations of
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 196916-25G | 04061837830174 |