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Merck
CN

00881

(±)-4-Hydroxypropranolol hydrochloride

analytical standard

别名:

1-[(4-Hydroxy-1-naphthyl)oxy]-3-(isopropylamino)- 2-propanol hydrochloride, 4′-Hydroxypropranolol hydrochloride, 4-{2-Hydroxy-3-[(1-methylethyl)amino]propoxy}-1-naphthalenol hydrochloride

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关于此项目

经验公式（希尔记法）:
C16H21NO3·HCl
化学文摘社编号:
14133-90-5
分子量:
311.80
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329747156
MDL number:
MFCD06656370
Beilstein/REAXYS Number:
4036845

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产品名称

(±)-4-Hydroxypropranolol hydrochloride, analytical standard

InChI

1S/C16H21NO3.ClH/c1-11(2)17-9-12(18)10-20-16-8-7-15(19)13-5-3-4-6-14(13)16;/h3-8,11-12,17-19H,9-10H2,1-2H3;1H

SMILES string

CC(C)NCC(O)COC1=CC=C(O)C2=CC=CC=C21.Cl

InChI key

ROUJENUXWIFONU-UHFFFAOYSA-N

grade

analytical standard

assay

≥98.5% (AT)
≥98.5% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

100

相关类别

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCL5746
BCCH1537
BCCC6246
BCBV6968

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S Narimatsu et al.
Biological & pharmaceutical bulletin, 24(9), 988-994 (2001-09-18)
Repetitive administration of propranolol (PL) in rats decreases the activities of cytochrome P450 (CYP) 2D enzyme(s) in hepatic microsomes. We examined the properties of 4-hydroxypropranolol (4-OH-PL) as an inactivator of rat liver microsomal CYP2D enzyme(s) using bunitrolol (BTL) 4-hydroxylation and
Y Masubuchi et al.
Biochemical pharmacology, 43(4), 757-762 (1992-02-18)
The mechanism of selective inhibition of propranolol hydroxylations after multiple administration of the drug was investigated by metabolic inhibition studies in rat liver microsomes. The time course of irreversible binding of a reactive metabolic intermediate(s) of propranolol to liver microsomal
F Moriya et al.
Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence, 26(5), 360-366 (1991-10-01)
Effect of ethanol administration on blood propranolol concentration (BPC) was investigated with rats. By oral administration of 20 mg/kg propranolol hydrochloride together with 1.5 g/kg of ethanol, it was suggested that there might be an increase in blood 4-hydroxypropranolol concentration
K Rowland et al.
British journal of clinical pharmacology, 38(1), 9-14 (1994-07-01)
1. The 4-hydroxylation of propranolol by rat and human liver microsomes is associated with formation of a chemically reactive species which binds irreversibly to cytochrome P4502D6 (CYP2D6) destroying its catalytic function. Therefore, the effect of propranolol treatment (80 mg twice
Wenying Jian et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(31), 3267-3276 (2010-11-09)
In recent years, increasing emphasis has been placed on quantitative characterization of drug metabolites for better insight into the correlation between metabolite exposure and toxicological observations or pharmacological efficacy. One common strategy for metabolite quantitation is to adopt the stable
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