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Merck
CN

00881

Supelco

(±)-4-Hydroxypropranolol hydrochloride

analytical standard

别名:

1-[(4-Hydroxy-1-naphthyl)oxy]-3-(isopropylamino)- 2-propanol hydrochloride, 4′-Hydroxypropranolol hydrochloride, 4-{2-Hydroxy-3-[(1-methylethyl)amino]propoxy}-1-naphthalenol hydrochloride

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关于此项目

经验公式（希尔记法）:
C16H21NO3·HCl
化学文摘社编号:
14133-90-5
分子量:
311.80
Beilstein:
4036845
MDL编号:
MFCD06656370
UNSPSC代码:
41116107
PubChem化学物质编号:
329747156
NACRES:
NA.24

主要文件

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等级

analytical standard

质量水平

100

方案

≥98.5% (AT)
≥98.5% (HPLC)

保质期

limited shelf life, expiry date on the label

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

forensics and toxicology
pharmaceutical (small molecule)

包装形式

neat

储存温度

2-8°C

SMILES字符串

CC(C)NCC(O)COC1=CC=C(O)C2=CC=CC=C21.Cl

InChI

1S/C16H21NO3.ClH/c1-11(2)17-9-12(18)10-20-16-8-7-15(19)13-5-3-4-6-14(13)16;/h3-8,11-12,17-19H,9-10H2,1-2H3;1H

InChI key

ROUJENUXWIFONU-UHFFFAOYSA-N

相关类别

其他说明

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCL5746
BCCH1537
BCCC6246
BCBV6968

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Propranolol 4- and 5-hydroxylation and N-desisopropylation by cloned human cytochrome P4501A1 and P4501A2.
M S Ching et al.
Drug metabolism and disposition: the biological fate of chemicals, 24(6), 692-694 (1996-06-01)
S Narimatsu et al.
Chemical research in toxicology, 8(5), 721-728 (1995-07-01)
We have characterized a chemically reactive propranolol (PL) metabolite which binds to proteins in rat liver microsomes. During incubation with rat liver microsomes (1 mg of protein) fortified with an NADPH-generating system, 4-hydroxypropranolol (4-OH-PL) quickly disappeared from the reaction medium
Takeshi Shimizudani et al.
Chemico-biological interactions, 183(1), 67-78 (2009-10-27)
Oxidative metabolism of propranolol (PL) enantiomers (R-PL and S-PL) to 4-hydroxypropranolol (4-OH-PL), 5-OH-PL and N-deisopropylpropranolol (NDP) was examined in hepatic microsomes from cynomolgus and marmoset monkeys and in small intestinal microsomes from monkeys and humans. In hepatic microsomes, levels of
Junko Miyano et al.
Biochemical pharmacology, 69(6), 941-950 (2005-03-08)
Pretreatment of Hep G2 cells with beta-naphthoflavone (BNF 1-25microM) significantly increased cytosolic sulfation activities of 4-hydroxypropranolol (4-OH-PL) racemate. The profile was similar to those of sulfations towards dopamine and triiodothyronine in the same cytosolic fractions. Kinetic studies of 4-OH-PL sulfation
V G Belolipetskaia et al.
Eksperimental'naia i klinicheskaia farmakologiia, 58(6), 56-59 (1995-11-01)
Pharmacokinetics of propranolol (P), 4-hydroxy-propranolol sulfate (4HOP-Sulf), and glucoronides of pharmacologically active S-enantiomer P (S-PG) and ballast R-enantiomer of P (R-PG) in the blood serum of 21 patients with chronic ischemic heart disease and/or arterial hypertension has been studied at
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