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01675

吖啶黄 盐酸盐

purum

别名:

3,6-二氨基-10-甲基吖啶氯化物盐酸盐, 吖啶黄

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关于此项目

化学文摘社编号:
8063-24-9
UNSPSC Code:
12171500
Beilstein/REAXYS Number:
6265525
MDL number:
MFCD00069039
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grade

purum

mp

260 °C (dec.) (lit.)

fluorescence

λex 463 nm; λem 490 nm in ethanol

suitability

suitable for fluorescence

SMILES string

[Cl-].Cl[H].Cl[H].Nc1ccc2cc3ccc(N)cc3nc2c1.C[n+]4c5cc(N)ccc5cc6ccc(N)cc46

InChI

1S/C14H13N3.C13H11N3.3ClH/c1-17-13-7-11(15)4-2-9(13)6-10-3-5-12(16)8-14(10)17;14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;;;/h2-8H,1H3,(H3,15,16);1-7H,14-15H2;3*1H

InChI key

MKLTXAHQKDVBLY-UHFFFAOYSA-N

General description

mixture of 3,6-diamino-10-methyl-acridiniumchloride hydrochloride and 3,6-diamino-acridine-dihydrochloride

Application

Acriflavine (Euflavine) is a fluorescent dye used as a biological stain and an antiseptic fungicide effective agent against parasitic infections. Acriflavine inhibits mitochondriogenesis.

Other Notes

3,6-二氨基-10-甲基吖啶（acriflavin）和3,6-二氨基吖啶（proflavin）的混合物

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Ezzatollah Keyhani et al.
Annals of the New York Academy of Sciences, 1171, 284-291 (2009-09-03)
Acriflavine is an antiseptic, fungicide, and effective agent against parasitic infections, inducing petite mutation in the yeast Saccharomyces cerevisiae and kinetoplast loss in Trypanosomidae. Here we showed that acriflavine caused both apoptosis and necrosis in the yeast Candida utilis. Cells
Mako Kawai et al.
Microbiology and immunology, 53(9), 481-486 (2009-08-26)
The antimicrobial action of acriflavine, a quaternary ammonium compound, on Staphylococcus aureus was studied by electron microscopic observation. The bactericidal activity of acriflavine was dose-dependent over the 4 hr of exposure time. Scanning electron micrographs showed a wavy wrinkled cell
KangAe Lee et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(42), 17910-17915 (2009-10-07)
HIF-1 is a heterodimeric transcription factor that mediates adaptive responses to hypoxia and plays critical roles in cancer progression. Using a cell-based screening assay we have identified acriflavine as a drug that binds directly to HIF-1alpha and HIF-2alpha and inhibits

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