01832
腺嘌呤9-β-D-阿拉伯呋喃糖苷
≥99.0% (HPLC)
别名:
9-β-D-阿拉伯呋喃糖基腺嘌呤, Ara-A, 阿糖腺苷
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经验公式（希尔记法）:
C10H13N5O4
化学文摘社编号:
分子量:
267.24
EC Number:
226-893-9
UNSPSC Code:
41106305
MDL number:
Beilstein/REAXYS Number:
624881
InChI
1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7+,10-/m1/s1
InChI key
OIRDTQYFTABQOQ-UHTZMRCNSA-N
SMILES string
Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3O
assay
≥99.0% (HPLC)
antibiotic activity spectrum
viruses
mode of action
DNA synthesis | interferes, enzyme | inhibits
General description
Chemical structure: nucleoside
Biochem/physiol Actions
细胞可渗透的腺苷酸环化酶抑制剂；在去污剂分散的大鼠脑制剂中，IC50 = 30 μM。
细胞可渗透的腺苷酸环化酶抑制剂；在去污剂分散的大鼠脑制剂中，IC50 = 30 μM。具有临床意义的抗病毒剂，尤其是通过抑制DNA聚合酶来对抗单纯疱疹病毒（HSV）。
法规信息
新产品
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Larryn W Peterson et al.
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We report the synthesis and biological evaluation of Ala-(Val-)l-Ser-CO(2)R prodrugs of 1, where a dipeptide promoiety is conjugated to the P(OH)(2) group of cidofovir (1) via esterification by the Ser side chain hydroxyl group and an ethyl group (4 and
Wei Shen et al.
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5'-O-D- and L-amino acid derivatives and 5'-O-(D- and L-amino acid methyl ester phosphoramidate) derivatives of vidarabine (ara-A) were synthesized as vidarabine prodrugs. Some compounds were equi- or more potent in vitro than vidarabine against two pox viruses and their uptake
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From metabolic considerations and prediction of an inhibitor-induced conformational change, novel adenosine deaminase (ADA) inhibitors with improved activities and oral bioavailability have been developed on the basis of our originally designed non-nucleoside ADA inhibitors. They demonstrated in vivo efficacy in
Inhibition of B virus (Macacine herpesvirus 1) by conventional and experimental antiviral compounds.
P W Krug et al.
Antimicrobial agents and chemotherapy, 54(1), 452-459 (2009-10-28)
B virus infection of humans results in high morbidity and mortality in as many as 80% of identified cases. The main objective of this study was to conduct a comparative analysis of conventional and experimental antiviral drug susceptibilities of B
Paul B Yu et al.
Nature chemical biology, 4(1), 33-41 (2007-11-21)
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