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Merck
CN

02252

(−)-肾上腺素

tested according to USP

别名:

(−)-肾上腺素, (R)-(−)-3,4-二羟基-α-（甲基氨甲基）苯甲醇, L-肾上腺素

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关于此项目

线性分子式:
(HO)2C6H3CH(OH)CH2NHCH3
化学文摘社编号:
51-43-4
分子量:
183.20
EC Number:
200-098-7
UNSPSC Code:
12352200
PubChem Substance ID:
24845246
Beilstein/REAXYS Number:
2368277
MDL number:
MFCD00002204

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InChI key

UCTWMZQNUQWSLP-VIFPVBQESA-N

InChI

1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1

SMILES string

CNC[C@H](O)c1ccc(O)c(O)c1

agency

tested according to USP

mp

215 °C (dec.) (lit.)

solubility

H2O: very slightly soluble, NaOH: very soluble, acetone: insoluble, alcohol: very slightly soluble, chloroform: insoluble, diethyl ether: insoluble, oil: insoluble, potassium hydroxide solution: very soluble

application(s)

pharmaceutical (small molecule)

storage temp.

2-8°C

Gene Information

rat ... Adra1a(29412), Adra2a(25083), Adrb1(24925), Adrb2(24176), Drd1a(24316), Drd2(24318)

Application

(-)-Epinephrine was used in fertilization medium for rinsing Cumulus-oocyte complexes (COC) during in vitro maturation.

Biochem/physiol Actions

肾上腺素受体激动剂。
(-)-Epinephrine enhances the IL-6 secretion and bioactivity from isolated perfused rat liver (IPRL).

Preparation Note

(-)-Epinephrine readily dissolves in aqueous solutions of mineral acids, KOH and NaOH. It is very slightly soluble in water and alcohol but is insoluble in chloroform, ether, acetone, oils as well as in aqueous solutions of ammonia and the alkali carbonates.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

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Lot/Batch Number

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J Liao et al.
The American journal of physiology, 268(4 Pt 2), R896-R901 (1995-04-01)
A bidirectional communication exists between the nervous system and the immune system. Evidence has accumulated suggesting that cytokines-immune peptides influence sympathetic neuronal survival and that cytokines can promote the secretion of catecholamines. Using an isolated perfused rat liver (IPRL) preparation
C Wrenzycki et al.
Human reproduction (Oxford, England), 16(5), 893-901 (2001-05-02)
Assisted reproduction technologies have made great progress during the last 15 years in most mammalian species, including humans. Growing evidence indicates that bovine pre-implantation development is a superior model for investigating early human development than the mouse. The purpose of
Popchai Ngamskulrungroj et al.
PloS one, 6(1), e16076-e16076 (2011-01-21)
Human and animal cryptococcosis due to an unusual molecular type of Cryptococcus gattii (VGII) emerged recently on Vancouver Island, Canada. Unlike C. neoformans, C. gattii causes disease mainly in immunocompetent hosts, despite producing a similar suite of virulence determinants. To
Xiaojie Yao et al.
Nature chemical biology, 2(8), 417-422 (2006-06-27)
G protein-coupled receptors (GPCRs) regulate a wide variety of physiological functions in response to structurally diverse ligands ranging from cations and small organic molecules to peptides and glycoproteins. For many GPCRs, structurally related ligands can have diverse efficacy profiles. To
Candice Bjornson et al.
The Cochrane database of systematic reviews, (2)(2), CD006619-CD006619 (2011-02-18)
Croup is a common childhood illness characterized by barky cough, stridor, hoarseness and respiratory distress. Children with severe croup are at risk for intubation. Nebulized epinephrine (NE) may prevent intubation. To evaluate the efficacy and safety of NE in children
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