03334
丹磺酰肼
for LC-MS derivatization, LiChropur™, ≥95% (HPLC)
别名:
5-(Dimethylamino)-1-naphthalenesulfonic hydrazide, 5-(二甲基氨基)萘-1-磺酰肼, Dns-Hz
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线性分子式:
(CH3)2NC10H6SO2NHNH2
化学文摘社编号:
分子量:
265.33
UNSPSC Code:
41116105
NACRES:
NA.22
PubChem Substance ID:
EC Number:
251-337-7
Beilstein/REAXYS Number:
2868662
MDL number:
InChI
1S/C12H15N3O2S/c1-15(2)11-7-3-6-10-9(11)5-4-8-12(10)18(16,17)14-13/h3-8,14H,13H2,1-2H3
InChI key
KPQYDVAFRDWIBW-UHFFFAOYSA-N
SMILES string
CN(C)c1cccc2c(cccc12)S(=O)(=O)NN
assay
≥95% (HPLC)
quality
LiChropur™
technique(s)
LC/MS: suitable
mp
126-130 °C (lit.)
suitability
conforms to structure for Infrared spectrum
Quality Level
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General description
Dansylhydrazine (DNSH) is a fluorescent reagent which is commonly utilized for derivatization of carbonyl compounds.
Application
Suitable for LC-MS derivatization.
DNSH has been used for the analytical derivatization of malondialdehyde prior to its determination in human plasma by liquid chromatography-mass spectrometry (LC-MS).
It may be used as a derivatization agent for thujone prior to its determination in white Italian vermouth samples by reversed phase LC with fluorescence detection combined with tandem MS and as a fluorescent label for the quantification of neuroactive steroids, alphaxalone and pregnanolone in plasma by isocratic reversed-phase high-performance liquid chromatography (RP-HPLC).
DNSH has been used for the analytical derivatization of malondialdehyde prior to its determination in human plasma by liquid chromatography-mass spectrometry (LC-MS).
It may be used as a derivatization agent for thujone prior to its determination in white Italian vermouth samples by reversed phase LC with fluorescence detection combined with tandem MS and as a fluorescent label for the quantification of neuroactive steroids, alphaxalone and pregnanolone in plasma by isocratic reversed-phase high-performance liquid chromatography (RP-HPLC).
Legal Information
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Determination of malondialdehyde in human plasma by fully automated solid phase analytical derivatization.
Lord, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 877(13), 1292-1298 (2009)
High-performance liquid chromatography of the neuroactive steroids alphaxalone and pregnanolone in plasma using dansyl hydrazine as fluorescent label: application to a pharmacokinetic-pharmacodynamic study in rats.
Visser, et al.
Journal of Chromatography. B, Biomedical Applications, 745(2), 357-363 (2000)
Determination of thujone by derivatization with dansylhydrazine and liquid chromatography.
Scott, et al.
Journal of Liquid Chromatography and Related Technologies, 27(6), 1071-1081 (2004)
Tomofumi Santa
Biomedical chromatography : BMC, 25(1-2), 1-10 (2010-11-09)
Liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) is one of the most prominent analytical techniques owing to its inherent selectivity and sensitivity. In LC/ESI-MS/MS, chemical derivatization is often used to enhance the detection sensitivity. Derivatization improves the chromatographic separation, and
S A Visser et al.
Journal of chromatography. B, Biomedical sciences and applications, 745(2), 357-363 (2000-10-24)
This report describes a rapid and sensitive analytical method for the quantification of the neuroactive steroids alphaxalone and pregnanolone in rat plasma using derivatization with dansyl hydrazine as fluorescent label. The method involves protein precipitation, alkaline derivatization and extraction of
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