03417
N-[2-(4-Hydroxyphenyl)acetyl]glycine
analytical standard
别名:
2-[2-(4-Hydroxyphenyl)acetamido]acetic acid, 4-Hydroxyphenylacetyl glycine
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关于此项目
经验公式（希尔记法）:
C10H11NO4
化学文摘社编号:
分子量:
209.20
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
3298883
InChI
1S/C10H11NO4/c12-8-3-1-7(2-4-8)5-9(13)11-6-10(14)15/h1-4,12H,5-6H2,(H,11,13)(H,14,15)
SMILES string
OC(CNC(CC1=CC=C(O)C=C1)=O)=O
InChI key
CPPDWYIPKSSNNM-UHFFFAOYSA-N
grade
analytical standard
assay
≥98.0% (HPLC)
shelf life
limited shelf life, expiry date on the label
application(s)
clinical testing
format
neat
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Hydroxyphenylacetylglycine is an acylglycine. Acylglycines are normally minor metabolites of fatty acids. However, the excretion of certain acylglycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction: acyl-CoA + glycine ↔ CoA + N-acylglycine. Hydroxyphenylacetylglycine is an endogenous human metabolite. It can be originated from the metabolism of tyramine, itself is a monoamine compound derived from the amino acid tyrosine. Hydroxyphenylacetylglycine can also be derived from the metabolism of 3,4-dihydroxyphenylalanine (L-DOPA). In the metabolism of tyrosine, this compound is involved in the reaction Hydroxyphenylacetyl-CoA + Glycine ↔ Hydroxyphenylacetylglycine + CoA, catalyzed by acyltransferase enzymes (EC 2.3.1.-). Hydroxyphenylacetylglycine has been identified in human biofluids.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
B L Goodwin et al.
Xenobiotica; the fate of foreign compounds in biological systems, 8(10), 629-651 (1978-10-01)
The metabolism and interrelationships of orally and intraperitoneally administered L-dopa, related amino acids and their metabolites have been studied 2. Amino acids were decarboxylated. N-Methyldopa formed dopamine but not epinine. D-Dopa was absorbed from the intestine and metabolized by a
K Tanaka et al.
Clinical chemistry, 26(13), 1847-1853 (1980-12-01)
A gas-chromatographic method for urinary organic acid analysis is described, designed to be used routinely for the diagnosis of organic aciduria. It involves extraction of urine with ethyl acetate, dehydration of extract residues, and trimethylsilylation. Organic acids are identified by
H S Ramsdell et al.
Biomedical mass spectrometry, 4(4), 220-225 (1977-08-01)
The mass spectra of the methyl esters of twenty-one metabolically important N-acylglycines are reported. The spectra are discussed in terms of their fragmentations and their application to studies of metabolic diseases. In particular, the high relative abundance of the peak
K Tanaka et al.
Clinical chemistry, 26(13), 1839-1846 (1980-12-01)
Gas-chromatographic retention indices are given, in terms of methylene units, for 155 metabolically important compounds (mostly organic acids) as trimethylsilyl derivatives on 10% OV-1 and 10% OV-17 columns. Comprehensive references on metabolic diseases that can be diagnosed by detection of
NEW METABOLITES OF P-TYRAMINE FROM THE URINE OF RATS.
T NAKAJIMA et al.
Biochimica et biophysica acta, 90, 37-44 (1964-07-15)
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