03780
乙二醇-双（2-氨基乙醚）-N,N,N′,N′-四乙酸
≥98.0% (T)
别名:
Chel™-DE, EGTA, 乙二醇醚二胺四乙酸, 乙烯-双（氧乙烯硝基）四乙酸, 依他酸
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关于此项目
线性分子式:
[-CH2OCH2CH2N(CH2CO2H)2]2
化学文摘社编号:
分子量:
380.35
EC Number:
200-651-2
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
1717370
MDL number:
assay
≥98.0% (T)
mp
241 °C (dec.) (lit.), ~250 °C (dec.)
SMILES string
OC(=O)CN(CCOCCOCCN(CC(O)=O)CC(O)=O)CC(O)=O
InChI
1S/C14H24N2O10/c17-11(18)7-15(8-12(19)20)1-3-25-5-6-26-4-2-16(9-13(21)22)10-14(23)24/h1-10H2,(H,17,18)(H,19,20)(H,21,22)(H,23,24)
InChI key
DEFVIWRASFVYLL-UHFFFAOYSA-N
Application
Ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid also referred to as EGTA or Egtazic acid is a chelating agent that facilitates the determination of calcium in the presence of magnesium. EGTA has also been used for preparing the cytoskeleton buffer used in whole-mount electron microscopy of the cytoskeleton.
一种螯合剂，可在镁存在的情况下对钙进行测定。
Biochem/physiol Actions
乙二醇双(2-氨基乙醚)四乙酸(EGTA)A是一种螯合剂，可在镁存在的情况下对钙进行测定。
EGTA is an aminopolycarboxylic acid that inhibits the calcium-activated potassium conductance during the hyperpolarization in hippocampal CA3 pyramidal cells. EGTA induces apoptosis in PC12 cells and stimulates (Ca2+-Mg2+)-ATPase in rat liver plasma membranes.
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存储类别
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Effects of EGTA on the calcium-activated afterhyperpolarization in hippocampal CA3 pyramidal cells.
Small, J. Victor
Cell Biol., 3, 285-291 (1998)
L Lindenboim et al.
Journal of neurochemistry, 64(3), 1054-1063 (1995-03-01)
Pheochromocytoma (PC12) cells have been shown to undergo apoptosis (programmed cell death) when deprived of serum and to be rescued by nerve growth factor, fibroblast growth factor, dibutyryl cyclic AMP, aurintricarboxylic acid, or exogenous expression of bcl-2. We show here
P A Schwartzkroin et al.
Science (New York, N.Y.), 210(4474), 1125-1126 (1980-12-05)
Intracellular recordings in the hippocampal slice preparation were made with electrodes filled with 0.2 molar potassium EGTA. The purpose was to investigate the role of calcium in mediating afterhyperpolarizations following bursts evoked by intracellular current pulses, arising spontaneously, or induced