03936
倍他米松21-戊酸酯
pharmaceutical impurity standard
别名:
Betamethasone Related Compound A (USP), Betamethasone impurity E (PhEur)
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关于此项目
经验公式（希尔记法）:
C27H37FO6
化学文摘社编号:
分子量:
476.58
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
InChI
1S/C27H37FO6/c1-5-6-7-23(32)34-15-22(31)27(33)16(2)12-20-19-9-8-17-13-18(29)10-11-24(17,3)26(19,28)21(30)14-25(20,27)4/h10-11,13,16,19-21,30,33H,5-9,12,14-15H2,1-4H3/t16-,19-,20-,21-,24-,25-,26-,27-/m0/s1
SMILES string
CCCCC(=O)OCC(=O)[C@@]1(O)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C
InChI key
FEROCCAEIIKMJT-SUYDQAKGSA-N
grade
analytical standard
assay
≥95.0% (HPLC)
shelf life
limited shelf life, expiry date on the label
impurities
≤10.0% related substances, ≤5.0% solvents, ≤5.0% water
application(s)
pharmaceutical (small molecule)
storage temp.
2-8°C
Quality Level
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General description
Betamethasone 21-valerate is an active pharmaceutical ingredient present in various topical pharmaceutical creams.
Application
Betamethasone 21-valerate may be used as a reference standard in the determination of betamethasone 21-valerate in counterfeit drugs using high-performance liquid chromatography coupled with electrospray ionization mass spectrometry (HPLC/ESI‐MS). It may be used as a pharmaceutical impurity standard in the quantification of impurities of betamethasone 21-valerate in topical pharmaceutical creams using high-performance liquid chromatography (HPLC).
法规信息
新产品
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An RP-HPLC method for the stability-indicating analysis of impurities of both fusidic acid and betamethasone-17-valerate in a semi-solid pharmaceutical dosage form.
Byrne J, et al.
Journal of Chromatographic Science, 53(9), 1498-1503 (2015)
Metabolism of topical drugs within the skin, in particular glucocorticoids.
K Kubota et al.
Current problems in dermatology, 21, 61-66 (1993-01-01)
F Henry et al.
Skin pharmacology and applied skin physiology, 12(4), 199-210 (1999-07-27)
To assess the effect of the position of a limb (dependency) on the cutaneous vasoconstrictor (blanching) assay (VCA) using topical corticosteroid preparations. Two studies were performed on the forearms of healthy volunteers using tristimulus reflectance colorimetric assessments. The first one
Analysis of betamethasone, dexamethasone and related compounds by liquid chromatography/electrospray mass spectrometry.
Arthur EK, et al.
Rapid Communications in Mass Spectrometry, 18(6), 678-684 (2004)
K Kubota et al.
Dermatology (Basel, Switzerland), 188(1), 13-17 (1994-01-01)
The metabolism of betamethasone 17-valerate was estimated using an artificial living skin equivalent (LSE). Betamethasone 17-valerate, betamethasone 21-valerate and betamethasone were measured by a normal-phase high-performance liquid chromatographic (HPLC) method. Betamethasone 17-valerate was added to the culture medium with or
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