05521
醛固酮
≥98.5% (UV)
别名:
11β，21-二羟基-3，20-二氧代-4-孕-18-烯醛, 11β，21-二羟孕-4-烯-3，18，20-三酮, 18-醛固酮, Reichstein X
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关于此项目
经验公式（希尔记法）:
C21H28O5
化学文摘社编号:
分子量:
360.44
EC Number:
200-139-9
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
3224996
assay
≥98.5% (UV)
storage temp.
2-8°C
SMILES string
C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@H](C(=O)CO)[C@]4(C[C@H](O)[C@H]23)C=O
InChI
1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1
InChI key
PQSUYGKTWSAVDQ-ZVIOFETBSA-N
Application
醛固酮的D-异构体被认为是具有生物活性的异构体。
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Other Notes
以醛和半缩醛的平衡混合物形式存在。
Sales restrictions may apply
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Nils van der Lubbe et al.
American journal of physiology. Renal physiology, 305(8), F1177-F1188 (2013-08-30)
During hypovolemia and hyperkalemia, the kidneys defend homeostasis by Na(+) retention and K(+) secretion, respectively. Aldosterone mediates both effects, but it is unclear how the same hormone can evoke such different responses. To address this, we mimicked hypovolemia and hyperkalemia
Daniel Pouly et al.
American journal of physiology. Renal physiology, 305(1), F21-F30 (2013-04-05)
Ubiquitylation plays an important role in the control of Na⁺ homeostasis by the kidney. It is well established that the epithelial Na⁺ channel ENaC is regulated by the ubiquitin-protein ligase NEDD4-2, limiting ENaC cell surface expression and activity. Ubiquitylation can
Geneviève Nguyen et al.
Hypertension (Dallas, Tex. : 1979), 63(2), 297-302 (2013-11-13)
A soluble (pro)renin receptor (sPRR) circulates in plasma and is able to bind renin and prorenin. It is not known whether plasma sPRR concentrations vary with the activity of the renin-angiotensin system. We measured plasma sPRR, renin, prorenin, and aldosterone
Ashraf H Ahmed et al.
The Journal of clinical endocrinology and metabolism, 99(8), 2745-2753 (2014-04-26)
Failure of aldosterone suppression by sodium loading during fludrocortisone suppression testing (FST) or saline suppression testing (SST) confirms primary aldosteronism (PA). We previously found recumbent SST (RSST) to lack sensitivity. Aldosterone levels can be higher upright (e.g. seated) than recumbent
Melanie P Chin et al.
Journal of cardiac failure, 20(12), 953-958 (2014-10-14)
A phase 3 randomized clinical trial was designed to test whether bardoxolone methyl, a nuclear factor erythroid-2-related factor 2 (Nrf2) activator, slows progression to end-stage renal disease in patients with stage 4 chronic kidney disease and type 2 diabetes mellitus.
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