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Merck
CN

06655

(R)-(-)-1-氨基乙基膦酸

≥97.0% (NT)

别名:

L-(-)-1-氨基乙基膦酸, L-Ala(P)

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关于此项目

线性分子式:
CH3CH(NH2)P(O)(OH)2
化学文摘社编号:
分子量:
125.06
UNSPSC Code:
12352116
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4291032
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assay

≥97.0% (NT)

optical activity

[α]20/D −4.8±0.5°, c = 5% in H2O

storage temp.

2-8°C

SMILES string

C[C@H](N)P(O)(O)=O

InChI

1S/C2H8NO3P/c1-2(3)7(4,5)6/h2H,3H2,1H3,(H2,4,5,6)/t2-/m1/s1

InChI key

UIQSKEDQPSEGAU-UWTATZPHSA-N

General description

(R)-(-)-1-Aminoethylphosphonic acid is a synthetic analog of L-alanine that shows antibacterial property.

Application

(R)-(−)-1-Aminoethylphosphonic acid can be used to prepare copper(II) heteroligand complexes, which are employed in the solution equilibrium studies.

Other Notes

在"P 端"具有此氨基酸类似物的二肽至四肽是青霉素类和脑脂质类的杀菌剂和协同增效剂


pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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分析证书(COA)

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Reaction of Alanine Racemase with 1-Aminoethylphosphonic Acid Forms a Stable External Aldimine
Stamper CGF, et al.
Biochemistry, 37(29), 10438-10445 (1998)
Stabilities and coordination modes of α-alaninephosphonic acid in copper (II) heteroligand complexes with ethylenediamine, diethylenetriamine or N, N, N′, N′, N″-pentamethyldiethylene triamine in aqueous solution
Kamecka A, et al.
Journal of Solution Chemistry, 40(6), 1041-1054 (2011)
J G Allen et al.
Antimicrobial agents and chemotherapy, 16(3), 306-313 (1979-09-01)
The metabolism and pharmacokinetics of a synthetic antibacterial phosphonodipeptide, alafosfalin, have been studied in rats, baboons, and human volunteers. The compound was rapidly absorbed from the injection site after subcutaneous and intramuscular administration and gave peak plasma concentrations at 15



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