跳转至内容
Merck
CN

06997

Supelco

(R)-2-Methyl-3-ureidopropionic acid

别名:

(2R)-3-[(Aminocarbonyl)amino]-2-methylpropanoic acid

登录查看公司和协议定价

选择尺寸


关于此项目

经验公式(希尔记法):
C5H10N2O3
化学文摘社编号:
分子量:
146.14
UNSPSC代码:
12352200
NACRES:
NA.24
技术服务
需要帮助?我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助?我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

方案

≥85% (HPLC)

质量水平

旋光性

[α]/D -19±2°, c = 0.1 in ethanol

包装形式

neat

储存温度

2-8°C

SMILES字符串

O=C(O[H])[C@@](C([H])([H])[H])([H])C([H])([H])N([H])C(N([H])[H])=O

生化/生理作用

This metabolite is increased in the urine of patients with beta-ureidopropionase deficiency and can be used to predict patient′s individual phenotypes of enzyme deficiencies in pyrimidine metabolism when associated with a risk for severe toxicity against the antineoplastic agent 5-fluorouracil.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本?

如果您需要特殊版本,可通过批号或批次号查找具体证书。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

NMR-based urinalysis for rapid diagnosis of ?-ureido- propionase deficiency in a patient with Dravet syndrome.
Lam, C.W., et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 440, 201-204 (2015)
Urinary metabonomics of stomach cancer assessed by rapid resolution liquid chromatography/time-of-flight mass spectrometry
Zhang, Y., et al.
Chinese Medical Journal (English Edition), 126, 1930-1933 (2013)
Ute Hofmann et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 791(1-2), 371-380 (2003-06-12)
Enzyme deficiencies in pyrimidine metabolism are associated with a risk for severe toxicity against the antineoplastic agent 5-fluorouracil. To assess whether urinary levels of pyrimidines and their metabolites can be used for predicting patients' individual phenotype, a new gas chromatographic-tandem
Morimasa Ohse et al.
Journal of mass spectrometry : JMS, 37(9), 954-962 (2002-09-25)
Dihydropyrimidine dehydrogenase (DHPDase), dihydropyrimidinase (DHPase) and beta-ureidopropionase (betaUPase) are the enzymes that catalyze the first, second, and third steps of the degradation of pyrimidines, respectively. beta-Ureidopropionate (betaUP) and beta-ureidoisobutyrate (betaUIB) are increased in the urine of patients with betaUPase deficiency.
André B P van Kuilenburg et al.
Biochimica et biophysica acta, 1822(7), 1096-1108 (2012-04-25)
ß-ureidopropionase is the third enzyme of the pyrimidine degradation pathway and catalyzes the conversion of N-carbamyl-ß-alanine and N-carbamyl-ß-aminoisobutyric acid to ß-alanine and ß-aminoisobutyric acid, ammonia and CO(2). To date, only five genetically confirmed patients with a complete ß-ureidopropionase deficiency have

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持