07635
氨基核苷嘌呤霉素
≥99.0% (HPLC)
别名:
3′-Amino-3′-deoxy-N6,N6-dimethyladenosine
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关于此项目
经验公式（希尔记法）:
C12H18N6O3
化学文摘社编号:
分子量:
294.31
EC Number:
200-388-3
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
93902
InChI
1S/C12H18N6O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-9(20)7(13)6(3-19)21-12/h4-7,9,12,19-20H,3,13H2,1-2H3/t6-,7+,9+,12-/m1/s1
InChI key
RYSMHWILUNYBFW-VENHTOENSA-N
SMILES string
CN(C)c1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@H](N)[C@@H]3O
assay
≥99.0% (HPLC)
solubility
H2O: 50 mg/mL, clear, slightly yellow
mode of action
protein synthesis | interferes
storage temp.
2-8°C
Yiqin Zuo et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 27(1), 174-181 (2011-05-14)
Peroxisome proliferator-activated receptor gamma (PPARγ) agonists have beneficial effects on renal structure and function in models of diabetes and chronic kidney diseases. However, the increased incidence of weight gain and edema potentially limits their usefulness. We studied an acute minimal-change
S Y Yu et al.
Transplantation proceedings, 45(2), 569-573 (2013-03-19)
Apoptosis, which is usually a response to the microenvironment, requires inactivation of prosurvival molecules. Apoptosis contributes to loss of podocytes in the course of renal injury, an event closely associated with the development of proteinuria. Dexamethasone (DEX) is the standard
Leyi Gu et al.
Kidney international, 81(5), 458-468 (2011-12-15)
In non-neuronal cells, glutamate is an extracellular signaling mediator. Since podocytes have glutamate-containing vesicles, we sought to determine glutamate receptor presence and action in glomerular cells. The metabotropic glutamate receptors (mGluR) 1, 5, 6, and 8 were found to be
Xuan Bu et al.
American journal of physiology. Renal physiology, 301(4), F784-F792 (2011-07-22)
Podocyte injury is considered to play important roles in the pathogenesis of human glomerular disease. There is accumulating evidence suggesting that hepatocyte growth factor (HGF) elicits preventive activity for glomerular cells in animal models of chronic renal diseases. In this
G N Marinides et al.
Kidney international, 37(2), 749-757 (1990-02-01)
The effects of dietary protein and converting enzyme inhibition (CEI) on chronic puromycin aminonucleoside nephropathy (PAN) were studied. PAN was induced with seven SQ injections of puromycin aminonucleoside 20 mg/kg over 10 weeks in male Sprague-Dawley rats. The rats were
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