InChI key
FUOOLUPWFVMBKG-UHFFFAOYSA-N
InChI
1S/C4H9NO2/c1-4(2,5)3(6)7/h5H2,1-2H3,(H,6,7)
SMILES string
CC(C)(N)C(O)=O
grade
puriss.
assay
≥99.0% (NT)
ign. residue
≤0.3%
mp
≥300 °C
application(s)
peptide synthesis
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Shun-ichi Wada et al.
Bioorganic & medicinal chemistry letters, 21(19), 5688-5691 (2011-08-31)
Cell-penetrating peptides (CPPs) are useful tools for the delivery of hydrophilic bioactive molecules, such as peptides, proteins, and oligonucleotides, across the cell membrane. To realize the delivery of therapeutic macromolecules by CPPs, the CPPs are required to show resistance to
Marta De Zotti et al.
Amino acids, 43(4), 1761-1777 (2012-04-10)
The lipopeptaibol trichogin GA IV is a natural, non-ribosomally synthesized, antimicrobial peptide remarkably resistant to the action of hydrolytic enzymes. This feature may be connected to the multiple presence in its sequence of the non-coded residue α-aminoisobutyric acid (Aib), which
Jamie E Elsila et al.
Astrobiology, 11(2), 123-133 (2011-03-23)
The presence of nonprotein α-dialkyl-amino acids such as α-aminoisobutyric acid (α-AIB) and isovaline (Iva), which are considered to be relatively rare in the terrestrial biosphere, has long been used as an indication of the indigeneity of meteoritic amino acids. However
Md Shahidul Islam et al.
Amino acids, 42(6), 2103-2110 (2011-06-04)
The naturally occurring cyclic tetrapeptide, chlamydocin, originally isolated from fungus Diheterospora chlamydosphoria, consists of α-aminoisobutyric acid, L-phenylalanine, D-proline and an unusual amino acid (S)-2-amino-8-((S)-oxiran-2-yl)-8-oxooctanoic acid (Aoe) and inhibits the histone deacetylases (HDACs), a class of regulatory enzymes. The epoxyketone moiety
Piero Geotti-Bianchini et al.
Organic & biomolecular chemistry, 8(6), 1315-1321 (2010-03-06)
Three thymine-based nucleo-heptapeptides, each containing two nucleo-amino acids and zero, one or four Aib residues, respectively, have been synthesized. A single Aib residue is enough to promote the adoption of a helical structure in our nucleopeptides and to increase significantly
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