09480
2-氨基噻唑
technical, ≥90% (NT)
别名:
2-噻唑胺
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关于此项目
经验公式（希尔记法）:
C3H4N2S
化学文摘社编号:
分子量:
100.14
EC Number:
202-511-6
UNSPSC Code:
12352100
PubChem Substance ID:
Beilstein/REAXYS Number:
105738
MDL number:
InChI key
RAIPHJJURHTUIC-UHFFFAOYSA-N
InChI
1S/C3H4N2S/c4-3-5-1-2-6-3/h1-2H,(H2,4,5)
SMILES string
Nc1nccs1
grade
technical
assay
≥90% (NT)
impurities
≤3% water
mp
85-92 °C
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
Ian Bruce et al.
Bioorganic & medicinal chemistry letters, 22(17), 5445-5450 (2012-08-07)
Using a parallel synthesis approach to target a non-conserved region of the PI3K catalytic domain a pan-PI3K inhibitor 1 was elaborated to provide alpha, delta and gamma isoform selective Class I PI3K inhibitors 21, 24, 26 and 27. The compounds
Sina Ghaemmaghami et al.
Journal of virology, 84(7), 3408-3412 (2009-12-25)
Prion diseases are fatal, untreatable neurodegenerative diseases caused by the accumulation of the misfolded, infectious isoform of the prion protein (PrP), termed PrP(Sc). In an effort to identify novel inhibitors of prion formation, we utilized a high-throughput enzyme-linked immunosorbent assay
Irene Lagoja et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 43(5), 386-392 (2011-06-15)
A novel series of 2-aminothiazoles with strong protection in an Alzheimer's disease (AD) model comprising tau-induced neuronal toxicity is disclosed. These derivatives can be synthesized in one-pot and a small SAR of the substitution within these series afforded several compounds
Zhili Liu et al.
Bioorganic & medicinal chemistry, 16(14), 6675-6681 (2008-06-20)
A series of apomorphine ((-)-1, APO)-derived analogues ((+/-)-3, (-)-4-(-)-6) were designed and synthesized by hybridizing APO with a privileged 2-aminothiazole functionality which was lent from the orally available anti-parkinsonian drug, pramipexole (2). Among these hybridized compounds, catecholic aporphine (-)-6 shows
Breland Smith et al.
Bioorganic & medicinal chemistry letters, 22(10), 3567-3570 (2012-04-21)
This Letter presents the synthesis and biological evaluation of a collection of 2-aminothiazoles as a novel class of compounds with the capability to reduce the production of PGE(2) in HCA-7 human adenocarcinoma cells. A total of 36 analogs were synthesized
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