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Merck
CN

10340

4-雄烯-3,17-二酮

purum, ≥98.0% (HPLC)

别名:

雄烯二酮

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关于此项目

经验公式(希尔记法):
C19H26O2
化学文摘社编号:
分子量:
286.41
EC Number:
200-554-5
UNSPSC Code:
51111800
MDL number:
Beilstein/REAXYS Number:
2059239
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grade

purum

assay

≥98.0% (HPLC)

optical activity

[α]20/D +189±2°, c = 1% in ethanol

drug control

USDEA Schedule IIIN; regulated under CDSA - not available from Sigma-Aldrich Canada

mp

170-173 °C

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)C(=O)CC[C@@]24[H]

InChI

1S/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1

InChI key

AEMFNILZOJDQLW-QAGGRKNESA-N

Biochem/physiol Actions

睾酮前体和具有雄激素活性的代谢物。
睾酮前体和具有雄激素活性的代谢物;可增大前列腺癌或胰腺癌的风险。

Other Notes

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法规信息

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Margarida M D S Cepa et al.
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Journal of medicinal chemistry, 48(16), 5257-5268 (2005-08-05)
Type 3 17beta-hydroxysteroid dehydrogenase (17beta-HSD) is involved in the biosynthesis of androgen testosterone. To produce potent inhibitors of this key steroidogenic enzyme, we prepared a series of androsterone (ADT) derivatives by adding a variety of substituents at position 3. The
Patrick Bydal et al.
European journal of medicinal chemistry, 44(2), 632-644 (2008-05-13)
Androgens are well known to play a predominant role in prostate cancer and other androgen-dependent diseases. To decrease the level of androgen testosterone in the prostate, we are interested in developing inhibitors of 17beta-hydroxysteroid dehydrogenase type 5 (17beta-HSD5). This enzyme
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Journal of medicinal chemistry, 51(7), 2047-2056 (2008-03-12)
A benchmark data set of steroids with known affinity for sex hormone-binding globulin (SHBG) has been widely used to validate popular molecular field-based QSAR techniques. We have expanded the data set by adding a number of nonsteroidal SHBG ligands identified
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Journal of medicinal chemistry, 51(19), 5932-5942 (2008-09-16)
The liver-specific organic cation transport protein (OCT1; SLC22A1) transports several cationic drugs including the antidiabetic drug metformin and the anticancer agents oxaliplatin and imatinib. In this study, we explored the chemical space of registered oral drugs with the aim of

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货号GTIN
278785-50G04061837837005
278785-10G04061837836992

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