10861
琥珀酰磺胺噻唑
~95% (TLC)
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关于此项目
经验公式（希尔记法）:
C13H13N3O5S2
化学文摘社编号:
分子量:
355.39
EC Number:
204-141-0
UNSPSC Code:
51101500
PubChem Substance ID:
Beilstein/REAXYS Number:
349989
MDL number:
InChI key
SKVLYVHULOWXTD-UHFFFAOYSA-N
InChI
1S/C13H13N3O5S2/c17-11(5-6-12(18)19)15-9-1-3-10(4-2-9)23(20,21)16-13-14-7-8-22-13/h1-4,7-8H,5-6H2,(H,14,16)(H,15,17)(H,18,19)
SMILES string
OC(=O)CCC(=O)Nc1ccc(cc1)S(=O)(=O)Nc2nccs2
assay
~95% (TLC)
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
DNA synthesis | interferes, enzyme | inhibits
General description
Chemical structure: sulfonamide
E O Uthus et al.
Biological trace element research, 58(1-2), 25-33 (1997-07-01)
A previous experiment using rats indicated that dietary nickel (Ni), folic acid, and their interaction affected variables associated with one-carbon metabolism. That study used diets that produced only mild folate deficiency. Thus, an experiment was performed to determine the effect
Tyrosine oxidation by livers from rats with a sulfasuxidine-induced pteroylglutamic acid deficiency.
G RODNEY et al.
The Journal of biological chemistry, 168(1), 395-395 (1947-04-01)
Intraperitoneal administration of succinylsulfathiazole and phthalylsulfathiazole; their use in the prophylaxis and treatment of peritonitis.
J P YOUNG et al.
Archives of surgery (Chicago, Ill. : 1920), 53, 182-189 (1946-08-01)
Succinylsulfathiazole in the nutrition of the rat.
L D WRIGHT et al.
The American journal of the medical sciences, 212(3), 312-314 (1946-09-01)
R L Walzem et al.
The Journal of nutrition, 118(11), 1343-1348 (1988-11-01)
Thiamin absorption and excretion were assessed in rats with severe folate deficiency (FD) by determining the fate of oral 3H-labeled and intravenous 14C-labeled thiamin over a 6-h test period. Thiamin status was evaluated in these same rats by measuring transketolase
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