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COO原产地证书/COA分析证书

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11480

壬二酸

Name: 壬二酸
Brand: SIAL

technical, ~85% (GC)

别名:

杜鹃花酸

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About This Item

线性分子式:

HO₂C(CH₂)₇CO₂H

CAS Number:

123-99-9

分子量:

188.22

Beilstein:

1101094

EC 号:

204-669-1

MDL编号:

MFCD00004432

UNSPSC代码:

12352100

PubChem化学物质编号:

329749451

NACRES:

NA.22

蒸汽密度

6.5 (vs air)

质量水平

200

蒸汽压

<1 mmHg ( 20 °C)

等级

technical

方案

~85% (GC)

沸点

286 °C/100 mmHg (lit.)

mp

109-111 °C (lit.)

官能团

carboxylic acid

SMILES字符串

OC(=O)CCCCCCCC(O)=O

InChI

1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)

InChI key

BDJRBEYXGGNYIS-UHFFFAOYSA-N

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一般描述

Azelaic acid (Nonanedioic acid) is a naturally occurring saturated, nonphenolic compound isolated from cultures Pityrosporum ovale. It is a therapeutic agent with well-known antibacterial properties.

应用

A phase 3 randomized, double-blind, vehicle-controlled trial of azelaic acid foam 15% in the treatment of papulopustular rosacea: This study evaluates the efficacy and safety of a 15% azelaic acid foam in treating rosacea, demonstrating significant improvements in disease severity (Draelos et al., 2015).
Comparison of the characteristics of transfersomes and protransfersomes containing azelaic acid: This research compares the properties of transfersome formulations with azelaic acid, highlighting their potential for enhanced delivery in dermatological applications (Rahmi and Pangesti, 2018).
Enhancing the bioconversion of azelaic acid to its derivatives by response surface methodology: This article discusses optimizing the production of azelaic acid derivatives, which are crucial for cosmetic and pharmaceutical applications (Khairudin et al., 2018).
Azelaic acid: a bio-based building block for biodegradable polymers: The study explores azelaic acid as a sustainable precursor for producing biodegradable polymers, pertinent to material science (Todea et al., 2021).
Preparation and evaluation of azelaic acid topical microemulsion formulation: in vitro and in vivo study: This research presents a microemulsion formulation of azelaic acid, assessing its stability and skin permeability, critical for topical therapeutic applications (Hung et al., 2021).

生化/生理作用

Azelaic acid is a potent inhibitor of 5α-reductase activity. It is a reversible competitive inhibitor of thioredoxin reductase in human melanoma cells.