11546
3′-叠氮-3′-脱氧胸苷
≥99.0% (HPLC)
别名:
AZT, ZDV, 叠氮胸苷, 齐多夫定
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关于此项目
经验公式（希尔记法）:
C10H13N5O4
化学文摘社编号:
分子量:
267.24
Beilstein:
3595791
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
生物来源
synthetic
方案
≥99.0% (HPLC)
表单
powder with small lumps
杂质
≤0.5% water
mp
113-115 °C (lit.)
溶解性
H2O: 50 mg/mL, clear, colorless to slightly yellow
储存温度
−20°C
SMILES字符串
CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O
InChI
1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
InChI key
HBOMLICNUCNMMY-XLPZGREQSA-N
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生化/生理作用
对 HIV-1 病毒有效的逆转录酶抑制剂。
其他说明
A potent, selective inhibitor of human immunodeficiency virus replication in MT-4 and ATH8 cells
警示用语：
Warning
危险声明
危险分类
Carc. 2 - Muta. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
A combination drug of abacavir-lamivudine-zidovudine (Trizivir) for treating HIV infection and AIDS.
Muki Shey et al.
The Cochrane database of systematic reviews, (3)(3), CD005481-CD005481 (2009-07-10)
The human immunodeficiency virus (HIV) has become one of the greatest challenges to global public health. In 2007 UNAIDS estimated that 33.2 million people were living with HIV. Currently recommended regimens for initiating HIV treatment consist of either a non-nucleoside
J Balzarini et al.
The Journal of biological chemistry, 264(11), 6127-6133 (1989-04-15)
3'-Azido-2',3'-dideoxythymidine (AZT) and 2',3'-didehydro-2',3'-dideoxythymidine (D4T) are potent and selective inhibitors of human immunodeficiency virus replication in MT-4 and ATH8 cells. They are also inhibitory to the replication of murine retroviruses, i.e. Moloney murine sarcoma virus-induced transformation of C3H cells. In
Temitope O Olomola et al.
Bioorganic & medicinal chemistry, 21(7), 1964-1971 (2013-02-19)
Baylis-Hillman-derived 3-(benzylaminomethyl)coumarins have been treated, sequentially, with chloroacetyl chloride and propargylamine to afford alkynylated coumarins as substrates for Click Chemistry reactions with azidothymidine (AZT) in the presence of a Cu(I) catalyst. The dual-action HIV-1 protease (PR) and reverse transcriptase (RT)
Aoife G Cotter et al.
The Journal of clinical endocrinology and metabolism, 98(4), 1659-1666 (2013-02-26)
In virologically suppressed, antiretroviral-treated patients, the effect of switching to tenofovir (TDF) on bone biomarkers compared to patients remaining on stable antiretroviral therapy is unknown. We examined bone biomarkers (osteocalcin [OC], procollagen type 1 amino-terminal propeptide, and C-terminal cross-linking telopeptide
Markus Moll et al.
European journal of immunology, 39(3), 902-911 (2009-02-07)
Invariant CD1d-restricted NKT cells play important roles in regulating both innate and adaptive immunity. They are targeted by HIV-1 infection and severely reduced in number or even lost in many infected subjects. Here, we have investigated the characteristics of NKT
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