11546
3′-叠氮-3′-脱氧胸苷
≥99.0% (HPLC)
别名:
AZT, ZDV, 叠氮胸苷, 齐多夫定
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C10H13N5O4
化学文摘社编号:
分子量:
267.24
PubChem Substance ID:
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
3595791
MDL number:
SMILES string
CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O
InChI
1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
InChI key
HBOMLICNUCNMMY-XLPZGREQSA-N
biological source
synthetic
assay
≥99.0% (HPLC)
form
powder with small lumps
impurities
≤0.5% water
mp
113-115 °C (lit.)
solubility
H2O: 50 mg/mL, clear, colorless to slightly yellow
storage temp.
−20°C
Biochem/physiol Actions
对 HIV-1 病毒有效的逆转录酶抑制剂。
Other Notes
A potent, selective inhibitor of human immunodeficiency virus replication in MT-4 and ATH8 cells
signalword
Warning
hcodes
Hazard Classifications
Carc. 2 - Muta. 2
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
J Balzarini et al.
The Journal of biological chemistry, 264(11), 6127-6133 (1989-04-15)
3'-Azido-2',3'-dideoxythymidine (AZT) and 2',3'-didehydro-2',3'-dideoxythymidine (D4T) are potent and selective inhibitors of human immunodeficiency virus replication in MT-4 and ATH8 cells. They are also inhibitory to the replication of murine retroviruses, i.e. Moloney murine sarcoma virus-induced transformation of C3H cells. In
Aoife G Cotter et al.
The Journal of clinical endocrinology and metabolism, 98(4), 1659-1666 (2013-02-26)
In virologically suppressed, antiretroviral-treated patients, the effect of switching to tenofovir (TDF) on bone biomarkers compared to patients remaining on stable antiretroviral therapy is unknown. We examined bone biomarkers (osteocalcin [OC], procollagen type 1 amino-terminal propeptide, and C-terminal cross-linking telopeptide
Markus Moll et al.
European journal of immunology, 39(3), 902-911 (2009-02-07)
Invariant CD1d-restricted NKT cells play important roles in regulating both innate and adaptive immunity. They are targeted by HIV-1 infection and severely reduced in number or even lost in many infected subjects. Here, we have investigated the characteristics of NKT
Comprehensive in vitro analysis of simian retrovirus type 4 susceptibility to antiretroviral agents.
Hiroaki Togami et al.
Journal of virology, 87(8), 4322-4329 (2013-02-01)
Simian retrovirus type 4 (SRV-4), a simian type D retrovirus, naturally infects cynomolgus monkeys, usually without apparent symptoms. However, some infected monkeys presented with an immunosuppressive syndrome resembling that induced by simian immunodeficiency virus infection. Antiretrovirals with inhibitory activity against
Temitope O Olomola et al.
Bioorganic & medicinal chemistry, 21(7), 1964-1971 (2013-02-19)
Baylis-Hillman-derived 3-(benzylaminomethyl)coumarins have been treated, sequentially, with chloroacetyl chloride and propargylamine to afford alkynylated coumarins as substrates for Click Chemistry reactions with azidothymidine (AZT) in the presence of a Cu(I) catalyst. The dual-action HIV-1 protease (PR) and reverse transcriptase (RT)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持