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Merck
CN

13750

青霉素G 钾盐

≥98.0% (HPLC)

别名:

苄青霉素 钾盐

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关于此项目

经验公式(希尔记法):
C16H17KN2O4S
化学文摘社编号:
分子量:
372.48
UNSPSC Code:
51101500
PubChem Substance ID:
eCl@ss:
34010400
EC Number:
204-038-0
Beilstein/REAXYS Number:
3832841
MDL number:
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assay

≥98.0% (HPLC)

optical activity

[α]20/D +290±5°, c = 2% in H2O

λ

0.2 % in H2O

UV absorption

λ: 264 nm Amax: ≤0.850, λ: 280 nm Amax: ≤0.100

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

SMILES string

[K+].[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)Cc3ccccc3)C([O-])=O

InChI

1S/C16H18N2O4S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1

InChI key

IYNDLOXRXUOGIU-LQDWTQKMSA-M

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General description

Chemical structure: β-lactam

Biochem/physiol Actions

作用机制:青霉素G通过与青霉素结合蛋白(PBP)结合抑制肽聚糖链交联,从而抑制细胞壁合成。

抗菌谱:本品具有抗革兰氏阳性菌和革兰氏阴性菌活性。

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

涉药品监管产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Mariagrazia Perilli et al.
Antimicrobial agents and chemotherapy, 57(2), 1047-1049 (2012-11-28)
Two laboratory mutant forms, TEM-149(H240) and TEM-149(H164-H240), of the TEM-149 extended-spectrum β-lactamase enzyme were constructed by site-directed mutagenesis. TEM-149(H240) and TEM-149(H164-H240) were similar in kinetic behavior, except with respect to benzylpenicillin and ceftazidime. Molecular modeling of the two mutant enzymes
Eleonor G Lago et al.
Sexually transmitted diseases, 40(2), 85-94 (2013-01-18)
The aim of this study was to investigate clinical features and outcomes of children treated for congenital syphilis (CS). Infants born alive in the public sector of São Lucas Hospital, Porto Alegre, Brazil, 1997 to 2004, whose mothers had syphilis
N Steele et al.
New Zealand veterinary journal, 62(1), 38-46 (2013-09-24)
To evaluate the efficacy of nil, three or six treatments of penethamate hydriodide on successive days for treatment of subclinical mastitis on the bacteriological cure proportion and subsequent somatic cell count (SCC). Milk samples were collected from all glands of
Li Li et al.
Drug metabolism and disposition: the biological fate of chemicals, 41(3), 659-667 (2013-01-09)
Antifolates, in particular methotrexate (MTX), have been widely used in the treatment of primary and secondary tumors of the central nervous system (CNS). Pemetrexed (PMX) is a novel antifolate that also exhibits potent antitumor activity against CNS malignancies. Studies have
Vasim Ahmed et al.
Journal of biotechnology, 163(4), 419-424 (2013-01-12)
In the present study, a novel strategy was adopted to synthesize, β lactamase resistant penicillin G molecules by using the unique properties of silver nanoparticles. Ascorbic acid-stabilized spherical monodispersed silver nanoparticles were prepared by a simple chemical reaction. The formation

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货号GTIN
381004-1G04061826732557

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