16237
2-[(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl acetate
pharmaceutical impurity standard
别名:
Aciclovir Related Compound A (USP), Aciclovir impurity A (PhEur)
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选择尺寸
关于此项目
经验公式（希尔记法）:
C10H13N5O4
化学文摘社编号:
分子量:
267.24
UNSPSC Code:
41116107
PubChem Substance ID:
MDL number:
InChI
1S/C10H13N5O4/c1-6(16)19-3-2-18-5-15-4-12-7-8(15)13-10(11)14-9(7)17/h4H,2-3,5H2,1H3,(H3,11,13,14,17)
SMILES string
CC(=O)OCCOCn1cnc2C(=O)NC(N)=Nc12
InChI key
DMHAXLGAKQREIL-UHFFFAOYSA-N
grade
analytical standard
assay
≥90.0% (HPLC)
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
impurities
≤10.0% HPLC impurities, ≤5% related solvents, ≤5% water
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
General description
2-[(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl acetate (impurity A) is the acetate form of acyclovir. It can be path indicative in the synthesis of acyclovir.
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
A L Huidobro et al.
Journal of pharmaceutical and biomedical analysis, 37(4), 687-694 (2005-03-31)
Acyclovir, guanine, and impurity A have been baseline separated with isocratic conditions at pH=3.0 and run time under 15 min by employing a SB-CN column from Agilent (150 mm x 4.6mm and 3.5 microm). Moreover, when run time was increased
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