16499
7-异丙氧基-3-苯基-4H-1-苯并吡喃-4-酮
analytical standard
别名:
（依普黄酮）
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关于此项目
经验公式（希尔记法）:
C18H16O3
化学文摘社编号:
分子量:
280.32
UNSPSC Code:
85151701
PubChem Substance ID:
MDL number:
InChI
1S/C18H16O3/c1-12(2)21-14-8-9-15-17(10-14)20-11-16(18(15)19)13-6-4-3-5-7-13/h3-12H,1-2H3
SMILES string
CC(C)Oc1ccc2c(OC=C(C2=O)c3ccccc3)c1
InChI key
SFBODOKJTYAUCM-UHFFFAOYSA-N
grade
analytical standard
assay
≥98.0% (HPLC)
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
mp
116-120 °C (lit.)
format
neat
Quality Level
General description
Ipriflavone, a flavonoid derivative of the natural isoflavone compound, plays a role in the mitochondrial phosphorylation and exhibits growth-promoting activity.
Application
Ipriflavone can be used as an analytical standard for the determination of the analyte in human and animal biological samples by liquid chromatography (LC) based methods.
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Simultaneous determination of ipriflavone and its main metabolites M1 and M5 in human plasma by liquid chromatography with tandem mass spectrometry
Ji HY, et al.
Analytical Letters, 38(1), 99-110 (2005)
Determination of ipriflavone and its synthetic impurities by high-performance liquid chromatography using diode-array detection
Sustacha K, et al.
Journal of Chromatography A, 719(1), 245-250 (1996)
Pharmacokinetics of ipriflavone, an isoflavone derivative, after intravenous and oral administration to rats: hepatic and intestinal first-pass effects
Kim SH and Lee MG
Life Sciences, 70(11), 1299-1315 (2002)
H J Chung et al.
Research in veterinary science, 85(1), 149-155 (2007-10-09)
It has been reported that ipriflavone was primarily metabolized via hepatic microsomal cytochrome P450 (CYP) 1A1/2 and 2C11 in rats, and the expression of hepatic CYP1A2 and 2C11 was not changed in rats with water deprivation for 72h compared to
Hye J Chung et al.
The Journal of pharmacy and pharmacology, 58(4), 449-457 (2006-04-07)
In order to find out what types of the hepatic microsomal cytochrome P450 (CYP) isozymes are involved in the metabolism of ipriflavone, ipriflavone at a dose of 20 mg kg(-1) (or 15 mg kg(-1)) was infused in male Sprague-Dawley rats.
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