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Merck
CN

17081

Sigma-Aldrich

Fura-2 LeakRes (AM)

≥95% (TLC)

别名:

Fura PE 3-AM

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关于此项目

经验公式（希尔记法）:
C55H63N5O29
化学文摘社编号:
172890-84-5
分子量:
1258.10
MDL编号:
MFCD00285848
UNSPSC代码:
12171500
PubChem化学物质编号:
329751473

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方案

≥95% (TLC)

溶解性

DMSO: soluble

荧光

λex 335 nm; λem 495 nm in 0.1 M Tris pH 8.0, esterase; 10 mM Ca2+

适用性

suitable for fluorescence

储存温度

−20°C

SMILES字符串

CC(=O)OCOC(=O)CN1CCN(CC1)C(=O)CCc2ccc(N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)c(OCCOc3cc4cc(oc4cc3N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)-c5ncc(o5)C(=O)OCOC(C)=O)c2

InChI

1S/C55H63N5O29/c1-33(61)76-27-82-49(68)22-57-11-13-58(14-12-57)48(67)10-8-39-7-9-41(59(23-50(69)83-28-77-34(2)62)24-51(70)84-29-78-35(3)63)44(17-39)74-15-16-75-45-18-40-19-46(54-56-21-47(89-54)55(73)87-32-81-38(6)66)88-43(40)20-42(45)60(25-52(71)85-30-79-36(4)64)26-53(72)86-31-80-37(5)65/h7,9,17-21H,8,10-16,22-32H2,1-6H3

InChI key

CGAZNAYDEAJZHQ-UHFFFAOYSA-N

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应用

Fura 2 is one of the most widely used calcium indicators for ratiometric measurement and is highly suitable for digital imaging microscopy.

特点和优势

Pale yellow gum. Cell permeable acetoxymethyl ester (AM) derivative of Fura-PE3 with spectral properties similar to the parent compound.

其他说明

Cell permeable ester of fluorescent calcium probe; abs.: λmax 364 nm; em.: λmax 502 nm

法规信息

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E P Milner et al.
The Journal of laboratory and clinical medicine, 131(1), 49-62 (1998-02-06)
High shear stress in narrowed arteries causes von Willebrand factor (vWf) to bind to its platelet receptor, glycoprotein Ib (GpIb). This binding is reported to promote an increase in intracellular free calcium concentration ((Ca2+)i), which may be responsible for platelet
F Abe et al.
British journal of pharmacology, 116(7), 3000-3004 (1995-12-01)
1. To examine whether cytosolic Ca2+ in smooth muscle cells distributes evenly, cytosolic Ca2+ levels were measured with two different Ca2+ indicators in the ferret isolated portal vein; a fluorescent indicator, fura-PE3, that shows the average Ca2+ level, and a
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 Ovarian cancer (OC) is the most lethal of the gynecologic cancers, and platinum-based treatment is a part of the standard first-line chemotherapy regimen. However, rapid development of acquired cisplatin resistance remains the main cause of treatment failure, and the underlying
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p66shc, a member of the shc adaptor protein family, has been shown to participate in regulation of mitochondrial homeostasis, apoptosis, and autophagosome formation. The present study was performed to investigate whether p66shc siRNA-encapsulated poly(d,l-lactic-co-glycolic acid) nanoparticles (p66shc siRNA-PLGA NPs) can

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