18545
3-溴-1,1,1-三氟丙酮
purum, ≥95.0% (GC)
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线性分子式:
CF3COCH2Br
化学文摘社编号:
分子量:
190.95
EC Number:
207-071-9
UNSPSC Code:
12352100
PubChem Substance ID:
Beilstein/REAXYS Number:
1703387
MDL number:
grade
purum
assay
≥95.0% (GC)
refractive index
n20/D 1.376 (lit.)
bp
87 °C/743 mmHg (lit.)
density
1.839 g/mL at 25 °C (lit.)
SMILES string
FC(F)(F)C(=O)CBr
InChI
1S/C3H2BrF3O/c4-1-2(8)3(5,6)7/h1H2
InChI key
ONZQYZKCUHFORE-UHFFFAOYSA-N
General description
3-Bromo-1,1,1-trifluoroacetone reacts with potassium enolate of ethyl 4,4,4-trifluoroacetoacetate to yield ethyl 2,4-bis(trifluoromethyl)-4-hydroxydihydro-3-furoate.
Application
3-Bromo-1,1,1-trifluoroacetone was used in the synthesis of:
- 3-nonylthio-1,1,1-trifluoropropan-2-one
- cyclic tetrapeptides containing trifluoromethyl and pentafluoroethyl ketone as zinc binding functional group
- perfluoroalkylated trans-allylic alcohols
法规信息
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M Brauer et al.
Biochemistry, 25(8), 2187-2191 (1986-04-22)
G-Actin is a globular protein (Mr 42 300) known to have three cysteine residues that are at least partially exposed and chemically reactive (Cys-10, -284, and -374). When G-actin was reacted with 3-bromo-1,1,1-trifluoropropanone, three resolvable 19F resonances were observed in
A combined nuclear magnetic resonance and absorbance stopped-flow apparatus for biochemical studies.
W A McGee et al.
Analytical biochemistry, 189(2), 267-273 (1990-09-01)
A combined NMR and absorbance stopped-flow has been developed for monitoring the kinetics of biochemical reactions. We demonstrate its usefulness in following the alkaline denaturation of human hemoglobin. No glassblowing is required in the fabrication of the apparatus. Commercially available
Binoy Jose et al.
Bioorganic & medicinal chemistry letters, 14(21), 5343-5346 (2004-09-30)
Cyclic tetrapeptides containing trifluoromethyl and pentafluoroethyl ketone as zinc binding functional group were synthesized as potent HDAC inhibitors. Evaluation by human HDAC inhibition assay and p21 promoter assay showed that these inhibitors are promising anticancer agents.
Novel reductive olefination mediated by Ti (Oi-Pr) 4 and Ph3P. One-pot synthesis of trifluoromethylated trans-allylic alcohols.
Shen Y, et al.
Chemical Communications (Cambridge, England), 20, 2195-2196 (1998)
M Bouchard et al.
Biochemistry, 37(9), 3149-3155 (1998-04-16)
We have investigated in the present study the interaction between G-actin and various types of liposomes, zwitterionic, positively charged, and negatively charged. To investigate at the molecular level the conformation of actin in the presence of lipids, we have selectively
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