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Merck
CN

21026

雨蛙素

≥97.0% (HPLC)

别名:

[Tyr(SO3H)4]雨蛙素, pGlu-Gln-Asp-Tyr(SO3H)-Thr-Gly-Trp-Met-Asp-Phe-NH2, 硫酸化蓝肽, 蓝肽, 雨蛙肽

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关于此项目

经验公式（希尔记法）:
C58H73N13O21S2
化学文摘社编号:
17650-98-5
分子量:
1352.40
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
5422487
MDL number:
MFCD00076478

主要文件

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InChI key

YRALAIOMGQZKOW-HJMGKOKZSA-N

SMILES string

CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)C(NC(=O)[C@H](Cc3ccc(OS(O)(=O)=O)cc3)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]4CCC(=O)N4)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc5ccccc5)C(N)=O

InChI

1S/C58H73N13O21S2/c1-29(72)49(71-57(87)40(23-31-12-14-33(15-13-31)92-94(89,90)91)68-56(86)43(26-48(78)79)69-52(82)37(16-18-44(59)73)65-51(81)36-17-19-45(74)63-36)58(88)62-28-46(75)64-41(24-32-27-61-35-11-7-6-10-34(32)35)54(84)66-38(20-21-93-2)53(83)70-42(25-47(76)77)55(85)67-39(50(60)80)22-30-8-4-3-5-9-30/h3-15,27,29,36-43,49,61,72H,16-26,28H2,1-2H3,(H2,59,73)(H2,60,80)(H,62,88)(H,63,74)(H,64,75)(H,65,81)(H,66,84)(H,67,85)(H,68,86)(H,69,82)(H,70,83)(H,71,87)(H,76,77)(H,78,79)(H,89,90,91)/t29-,36+,37+,38+,39+,40+,41+,42+,43+,49?/m1/s1

assay

≥80% peptide basis, ≥97.0% (HPLC)

solubility

0.05 M ammonium hydroxide: 1 mg/mL, clear, colorless

storage temp.

−20°C

Biochem/physiol Actions

对疼痛感知的影响是相互矛盾的。它可以预防胆囊疼痛、肾绞痛和间歇性跛行疼痛；然而，一般来说，它是内源性阿片类药物的拮抗剂。

Other Notes

A cholecystokinin analog. Review; In studies on protease zymogens

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

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Active polypeptides of nonmammalian origin.
G Bertaccini
Pharmacological reviews, 28(2), 127-177 (1976-06-01)
W Steinhilber et al.
Proceedings of the National Academy of Sciences of the United States of America, 85(18), 6597-6601 (1988-09-01)
Infusion of rats with optimal doses of caerulein for up to 24 hr resulted in divergent changes in protein synthesis in the exocrine pancreas: a 3-fold increase in synthesis of anionic trypsinogen and a 75% decrease in synthesis of amylase.
Dinesh Srinivasan et al.
Biochimie, 95(2), 429-435 (2012-11-13)
Peptidomic analysis of norepinephrine-stimulated skin secretions of the tetraploid clawed frog Xenopus laevis (Pipidae) led to the identification of 10 peptides with the ability to stimulate the release of insulin from the rat BRIN-BD11 clonal β cell line. These peptides
Christoph B Westphalen et al.
Methods in molecular biology (Clifton, N.J.), 980, 291-300 (2013-01-30)
Pancreatic cancer is a uniformly lethal disease characterized by a strong stromal reaction called desmoplasia. Organ fibrosis is also a feature of chronic pancreatitis a known risk factor for pancreatic cancer. Here we describe a transplantation approach to investigate bone
Jie Xiong et al.
Journal of ethnopharmacology, 145(2), 573-580 (2012-12-04)
Shikonin, a highly liposoluble naphthoquinone pigment isolated from the traditional medical herbs Lithospermum erythrorhizon (LE), was considered to exhibit an anti-inflammatory property. While the potential of shikonin to ameliorate acute pancreatitis (AP) is unknown. Our aim was to investigate the
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