assay
≥90% (sum of enantiomers, HPLC)
mp
260 °C (dec.) (lit.)
mode of action
DNA synthesis | interferes, enzyme | inhibits
SMILES string
CC[C@@]1(O)C(=O)OCC2=C1C=C3N(Cc4cc5ccccc5nc34)C2=O
InChI
1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
InChI key
VSJKWCGYPAHWDS-FQEVSTJZSA-N
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Other Notes
Eukaryotic DNA topoisomerase I poison. Used to study the interaction of topo I with DNA; DNA topoisomerases, review
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Muta. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
M.-A. Bjornsti
Current Opinion in Structural Biology, 1, 99-99 (1991)
S E Porter et al.
Nucleic acids research, 17(21), 8521-8532 (1989-11-11)
The eukaryotic topoisomerase I (topo I) is the target of the cytotoxic alkaloid camptothecin (CTT). In vitro, CTT enhances the breakage of DNA by topo I when the reaction is stopped with detergent. Although breakage at some sites is enhanced
DNA topoisomerase poisons as antitumor drugs.
L F Liu
Annual review of biochemistry, 58, 351-375 (1989-01-01)
Carmen Losasso et al.
Nucleic acids research, 36(17), 5635-5644 (2008-09-06)
Human DNA topoisomerase I (hTop1p) catalyzes the relaxation of supercoiled DNA and constitutes the cellular target of the antitumor drug camptothecin (CPT). The X-ray crystal structure of the enzyme covalently joined to DNA and bound to the CPT analog Topotecan
Andrea K McCollum et al.
Molecular cancer therapeutics, 7(10), 3256-3264 (2008-10-15)
Benzoquinone ansamycin antibiotics such as geldanamycin (GA) bind to the NH(2)-terminal ATP-binding domain of heat shock protein (Hsp) 90 and inhibit its chaperone functions. Despite in vitro and in vivo studies indicating promising antitumor activity, derivatives of GA, including 17-allylaminogeldanamycin
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