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Merck
CN

22760

氯乙醛 溶液

technical, ~55% in H2O (T)

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线性分子式:
ClCH2CHO
化学文摘社编号:
分子量:
78.50
EC Number:
203-472-8
UNSPSC Code:
12352100
PubChem Substance ID:
Beilstein/REAXYS Number:
1071226
MDL number:
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grade

technical

concentration

~55% in H2O (T)

refractive index

n20/D 1.407

density

1.217 g/mL at 20 °C

SMILES string

[H]C(=O)CCl

InChI

1S/C2H3ClO/c3-1-2-4/h2H,1H2

InChI key

QSKPIOLLBIHNAC-UHFFFAOYSA-N

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General description

Chloroacetaldehyde causes base-pair substitution in Salmonella typhimurium TA1535.

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 3 Oral - Aquatic Acute 1 - Carc. 2 - Eye Dam. 1 - Skin Corr. 1B - STOT SE 3

target_organs

Respiratory system

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

143.6 °F - closed cup

flash_point_c

62 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

法规信息

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分析证书(COA)

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U Rannug et al.
Chemico-biological interactions, 12(3-4), 251-263 (1976-03-01)
Previous investigations have shown that the carcinogen vinyl chloride causes base-pair substitution in the bacterium Salmonella typhimurium. The ability of four conceivable metabolites-chloroethylene oxide, chloroacetaldehyde, 2-chloroethanol and chloroacetic acid-to cause base-pair substitution directly in Salmonella typhimurium TA1535 has been compared.
Stephanie L MacAllister et al.
Chemico-biological interactions, 202(1-3), 259-266 (2012-12-12)
Cyclophosphamide and ifosfamide are two commonly used DNA-alkylating agents in cancer chemotherapy that undergo biotransformation to several toxic and non-toxic metabolites, including acrolein and chloroacetaldehyde (CAA). Acrolein and CAA toxicities occur by several different mechanisms, including ROS formation and protein
Burhan Knouzy et al.
Toxicology in vitro : an international journal published in association with BIBRA, 24(1), 99-107 (2009-09-08)
Chloroacetaldehyde, one of the main products of hepatic ifosfamide metabolism, contributes to its nephrotoxicity. However, the pathophysiology of this toxicity is not fully understood. The present work examined the time and dose effects of clinically relevant concentrations of chloroacetaldehyde (25-75microM)
Min Young Kim et al.
Chemical research in toxicology, 20(8), 1075-1083 (2007-07-31)
2-Chloroacetaldehyde (CAA), a metabolite of the carcinogen vinyl chloride, reacts with DNA to form cyclic etheno ()-lesions. AlkB, an iron-/alpha-ketoglutarate-dependent dioxygenase, repairs 1, N (6)-ethenodeoxyadenosine (A) and 3, N (4)-ethenodeoxycytidine (C) in site-specifically modified single-stranded viral genomes in vivo and
Leila Choucha-Snouber et al.
Biotechnology and bioengineering, 110(2), 597-608 (2012-08-14)
In this article, we present a liver-kidney co-culture model in a micro fluidic biochip. The liver was modeled using HepG2/C3a and HepaRG cell lines and the kidney using MDCK cell lines. To demonstrate the synergic interaction between both organs, we

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