24104
4′-氯地西泮
≥98.0% (CHN)
别名:
7-氯-5-（4-氯苯基）-1,3-二氢-1-甲基-2H-1,4-苯二氮卓-2-酮, Ro 5-4864, Ro5-4864
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关于此项目
经验公式（希尔记法）:
C16H12Cl2N2O
化学文摘社编号:
分子量:
319.19
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
685202
MDL number:
assay
≥98.0% (CHN)
drug control
regulated under CDSA - not available from Sigma-Aldrich Canada
mp
160-163 °C
SMILES string
O=C1CN=C(C2=CC=C(Cl)C=C2)C3=CC(Cl)=CC=C3N1C
InChI
1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3
InChI key
PUMYFTJOWAJIKF-UHFFFAOYSA-N
Other Notes
Diazepam analog which binds very strongly to peripheral benzodiazepine receptors, but has negligible affinity for central receptors.
R.H. Anholt
Trends in Pharmacological Sciences, 7, 506-506 (1986)
S Mukherjee et al.
Current molecular medicine, 12(4), 443-457 (2012-02-22)
Several molecular and cellular markers are currently used as prognostic indicators for diagnosis and therapeutic intervention of breast cancer. Although some of these markers have helped clinicians provide an earlier diagnosis (or prognosis), they have failed to provide adequate information
Wojciech Miltyk et al.
European journal of pharmacology, 647(1-3), 31-36 (2010-09-10)
Degenerative joint diseases are related to the excessive degradation of collagen and proteoglycans in cartilage. One of the potent inflammatory mediators of cartilage metabolism is interleukin-1 (IL-1) that has been implicated in the pathogenesis of degenerative joint diseases. Peripheral benzodiazepine
L Veenman et al.
Current molecular medicine, 12(4), 398-412 (2012-02-22)
The mitochondrial 18 kDa Translocator Protein (TSPO) was first detected by its capability to bind benzodiazepines in peripheral tissues and later also in glial cells in the brain, hence its previous most common name peripheral benzodiazepine receptor (PBR). TSPO has
Lufang Zhou et al.
Journal of molecular and cellular cardiology, 51(5), 632-639 (2011-06-08)
Local control of Ca(2+)-induced Ca(2+) release (CICR) depends on the spatial organization of L-type Ca(2+) channels and ryanodine receptors (RyR) in the dyad. Analogously, Ca(2+) uptake by mitochondria is facilitated by their close proximity to the Ca(2+) release sites, a
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