26060
氯丙嗪 盐酸盐
≥95.0% (AT)
别名:
2-氯-10-(3-二甲氨基丙基)吩噻嗪 盐酸盐, CPZ, 氯普马嗪
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关于此项目
经验公式（希尔记法）:
C17H19ClN2S · HCl
化学文摘社编号:
分子量:
355.33
EC Number:
200-701-3
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
3779989
assay
≥95.0% (AT)
ign. residue
≤0.1%
SMILES string
Cl[H].CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13
InChI
1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H
InChI key
FBSMERQALIEGJT-UHFFFAOYSA-N
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Application
在血红蛋白和过氧化物酶的微量测定中替代联苯胺、邻联茴香胺和邻联甲苯胺。
Biochem/physiol Actions
吩噻嗪类抗精神病药;D2 多巴胺受体拮抗剂，H1 组胺受体拮抗剂;抑制钙调蛋白依赖性环核苷酸磷酸二酯酶和一氧化氮合成酶的活化。
氯丙嗪表现出对白血病细胞的细胞毒性和抗增殖活性，但是不会影响正常淋巴细胞的活力。
Other Notes
Uncouples and inhibits oxidative phoshorylation at 10-3-10-4 M; Interaction of phenothiazine antipsychotics with calmodulin
法规信息
新产品
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The mechanism of action of chlorpromazine. Reduced diphosphopyridine nucleotidecytochrome c reductase and coupled phosphorylation.
M J DAWKINS et al.
The Biochemical journal, 73, 16-23 (1959-09-01)
B Weiss et al.
Biochemical pharmacology, 31(13), 2217-2226 (1982-07-01)
Calmodulin is a widely distributed, highly active, calcium-binding protein that influences a number of important biological events. Accordingly, agents that inhibit the activity of calmodulin should have profound pharmacological effects. Within the past few years, a number of compounds have
The effect of chlorpromazine on the respiratory chain; cytochrome oxidase.
M J DAWKINS et al.
The Biochemical journal, 72(2), 204-209 (1959-06-01)
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