optical activity
[α]20/D −15±5°, c = 1% in H2O
impurities
~3% total nitrogen (N), ~7% total S
loss
≤10% loss on drying
solubility
H2O: 10 mg/mL, clear, colorless
suitability
suitable as substrate for chondroitinase test
Application
Chondroitin, a glucosaminoglycan (GAG), is a polysaccharide chain of alternating units of N-acetylgalactosamine (GalNAc) and glucuronic acid (GlcA) that can be sulfated on the either or both GalNAc and GlcA units. Chondroitin and its sulfates are frequently attached to proteins to form proteoglycans.
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Katriina Lipponen et al.
Analytical chemistry, 83(15), 6040-6046 (2011-06-10)
Two different experimental approaches were used for obtaining a comprehensive view and understanding of the interactions between apolipoprotein B-100 (ApoB-100) of low-density lipoprotein and apolipoprotein E (ApoE) of high-density lipoprotein and chondroitin-6-sulfate (C6S) of arterial proteoglycan. The techniques employed were
Christian Stock et al.
Journal of cellular physiology, 226(10), 2641-2650 (2011-07-28)
In vivo, cells are embedded in an environment generated and maintained by multiple cell-cell and cell-matrix interactions. While transiting the dermis metastasizing melanoma cells interact with the extracellular matrix (ECM) and fibroblasts. To study the roles of ECM components and
G Cilpa et al.
The journal of physical chemistry. B, 115(16), 4818-4825 (2011-04-05)
A force field has been previously designed for a dodecasaccharide chain of chondroitin-6-sulfate (C6S) and has proved to yield valuable data going from basic conformational properties to a more detailed H-bonding network. This force field is further used here to
Antonella Sgambato et al.
Molecules (Basel, Switzerland), 25(19) (2020-09-27)
The regeneration of the nervous system is a challenging task. Currently, regenerative medicine approaches that exploit nature-inspired cues are being studied and hold great promise. The possibility to use protein-based matrices functionalized with small oligo- and monosaccharides is of interest
S Plesinac et al.
Clinical and experimental obstetrics & gynecology, 40(2), 307-308 (2013-08-27)
The authors present the case of a nulliparous 34-year-old patient. At the tenth week of gestation, she developed phlebothrombosis of veins of the right leg and massive pulmonary embolism. After thrombolytic and heparin therapy she developed rethrombosis and heparin-induced thrombocytopenia
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