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Merck
CN

27525

Sigma-Aldrich

L-Citrulline 7-amido-4-methylcoumarin hydrobromide

≥98.0% (sum of enantiomers, HPLC)

别名:

L-Citrulline 4-methyl-7-coumarinylamide hydrobromide

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关于此项目

经验公式(希尔记法):
C16H20N4O4 · HBr
化学文摘社编号:
分子量:
413.27
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
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方案

≥98.0% (sum of enantiomers, HPLC)

储存温度

2-8°C

SMILES字符串

Br[H].CC1=CC(=O)Oc2cc(NC(=O)[C@@H](N)CCCNC(N)=O)ccc12

InChI

1S/C16H20N4O4.BrH/c1-9-7-14(21)24-13-8-10(4-5-11(9)13)20-15(22)12(17)3-2-6-19-16(18)23;/h4-5,7-8,12H,2-3,6,17H2,1H3,(H,20,22)(H3,18,19,23);1H/t12-;/m0./s1

InChI key

XYOHUMXDURSJOW-YDALLXLXSA-N

应用

L-Citrulline 7-amido-4-methylcoumarin is used as a sensitive fluorogenic substrate for citrulline ureidase, yielding a blue solution upon cleavage.

其他说明

Substrate for proteases

象形图

Exclamation mark

警示用语:

Warning

危险声明

预防措施声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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N J MARCHETTE et al.
Journal of bacteriology, 82, 26-32 (1961-07-01)
Marchette, Nyven J. (University of Utah, Salt Lake City), and Paul S. Nicholes. Virulence and citrulline ureidase activity of Pasteurella tularensis. J. Bacteriol. 82:26-32. 1961.-The presence of a citrulline ureidase system in Pasteurella tularensis strains of high virulence, and its
J E Sheppeck et al.
Bioorganic & medicinal chemistry letters, 10(23), 2639-2642 (2000-12-29)
A statistically exhaustive, 8800 compound tripeptidal amidomethylcoumarin library was synthesized as discreet compounds using solid-phase combinatorial chemistry. A subset of the compounds was purified by HPLC and tested in a high-throughput fluorometric assay against several known serine and cysteine proteases
J E Clarridge et al.
Journal of clinical microbiology, 34(8), 1995-2000 (1996-08-01)
We have isolated two phenotypically distinct nonfastidious Francisella strains (Fx1 and Fx2) from the blood of compromised patients with pneumonia and compared them with eight other Francisella strains, including Francisella tularensis biovar tularensis, F. tularensis biovar novicida, and F. philomiragia.
Manish Mahawar et al.
Journal of bacteriology, 191(15), 4798-4806 (2009-06-09)
The citrulline ureidase (CTU) activity has been shown to be associated with highly virulent Francisella tularensis strains, including Schu S4, while it is absent in avirulent or less virulent strains. A definitive role of the ctu gene in virulence and

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