27525
L-Citrulline 7-amido-4-methylcoumarin hydrobromide
≥98.0% (sum of enantiomers, HPLC)
别名:
L-Citrulline 4-methyl-7-coumarinylamide hydrobromide
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关于此项目
经验公式（希尔记法）:
C16H20N4O4 · HBr
化学文摘社编号:
分子量:
413.27
UNSPSC Code:
12352209
PubChem Substance ID:
MDL number:
InChI
1S/C16H20N4O4.BrH/c1-9-7-14(21)24-13-8-10(4-5-11(9)13)20-15(22)12(17)3-2-6-19-16(18)23;/h4-5,7-8,12H,2-3,6,17H2,1H3,(H,20,22)(H3,18,19,23);1H/t12-;/m0./s1
SMILES string
Br[H].CC1=CC(=O)Oc2cc(NC(=O)[C@@H](N)CCCNC(N)=O)ccc12
InChI key
XYOHUMXDURSJOW-YDALLXLXSA-N
assay
≥98.0% (sum of enantiomers, HPLC)
storage temp.
2-8°C
Quality Level
Application
L-Citrulline 7-amido-4-methylcoumarin is used as a sensitive fluorogenic substrate for citrulline ureidase, yielding a blue solution upon cleavage.
Other Notes
Substrate for proteases
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
J E Sheppeck et al.
Bioorganic & medicinal chemistry letters, 10(23), 2639-2642 (2000-12-29)
A statistically exhaustive, 8800 compound tripeptidal amidomethylcoumarin library was synthesized as discreet compounds using solid-phase combinatorial chemistry. A subset of the compounds was purified by HPLC and tested in a high-throughput fluorometric assay against several known serine and cysteine proteases
N J MARCHETTE et al.
Journal of bacteriology, 82, 26-32 (1961-07-01)
Marchette, Nyven J. (University of Utah, Salt Lake City), and Paul S. Nicholes. Virulence and citrulline ureidase activity of Pasteurella tularensis. J. Bacteriol. 82:26-32. 1961.-The presence of a citrulline ureidase system in Pasteurella tularensis strains of high virulence, and its
J E Clarridge et al.
Journal of clinical microbiology, 34(8), 1995-2000 (1996-08-01)
We have isolated two phenotypically distinct nonfastidious Francisella strains (Fx1 and Fx2) from the blood of compromised patients with pneumonia and compared them with eight other Francisella strains, including Francisella tularensis biovar tularensis, F. tularensis biovar novicida, and F. philomiragia.
Manish Mahawar et al.
Journal of bacteriology, 191(15), 4798-4806 (2009-06-09)
The citrulline ureidase (CTU) activity has been shown to be associated with highly virulent Francisella tularensis strains, including Schu S4, while it is absent in avirulent or less virulent strains. A definitive role of the ctu gene in virulence and
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