27545
可乐定 盐酸盐
≥98.0% (TLC)
别名:
[2-(2,6-二氯苯基)亚氨基]咪唑烷 盐酸盐
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关于此项目
经验公式（希尔记法）:
C9H9Cl2N3 · HCl
化学文摘社编号:
分子量:
266.55
EC Number:
224-121-5
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
4163525
MDL number:
assay
≥98.0% (TLC)
impurities
≤1% water
solubility
H2O: 50 mg/mL, clear, colorless
storage temp.
2-8°C
SMILES string
Cl[H].Clc1cccc(Cl)c1NC2=NCCN2
InChI
1S/C9H9Cl2N3.ClH/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9;/h1-3H,4-5H2,(H2,12,13,14);1H
InChI key
ZNIFSRGNXRYGHF-UHFFFAOYSA-N
Gene Information
human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)
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Other Notes
Interacts with α-adrenergic receptors
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Inhalation - Acute Tox. 3 Oral
存储类别
6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
D Atlas et al.
European journal of biochemistry, 113(3), 521-529 (1981-01-01)
Clonidine and several analogues of clonidine are shown to be useful probes for alpha 2-adrenergic receptors in a comparative study of ligand binding and inhibition of adenylate cyclase. The alpha-adrenergic properties of a new potential probe, N-(4-hydroxyphenacetyl)-4-aminoclonidine hydrochloride, are described.
Nesreen M I M Elkomy et al.
European journal of pharmacology, 824, 148-156 (2018-02-17)
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Paula E Park et al.
Addiction biology, 20(2), 275-284 (2013-12-18)
Opioids represent effective drugs for the relief of pain, yet chronic opioid use often leads to a state of increased sensitivity to pain that is exacerbated during withdrawal. A sensitization of pain-related negative affect has been hypothesized to closely interact
Craige C Wrenn et al.
Neuroscience letters, 585, 109-113 (2014-11-30)
Fragile X syndrome (FXS), a disorder caused by a mutation in the FMR1 gene, is often associated with Attention Deficit Hyperactivity Disorder (ADHD). Common treatments for the hyperactivity often seen in ADHD involve the use of stimulants and α2-adrenergic agonists.
Yanyan Qiu et al.
Scientific reports, 4, 6605-6605 (2014-10-14)
This study examined whether a novel imidazoline I₂ receptor ligand CR4056 could serve as a discriminative stimulus and whether it shares similar discriminative stimulus effects with other reported I₂ receptor ligands. Eight male Sprague-Dawley rats were trained to discriminate 10.0 mg/kg
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