27650
秋水仙碱
≥96.0% (HPLC)
别名:
(S)-N-(5,6,7,9-四氢-1,2,3,10-四甲氧基-9-氧苯并[a]庚搭烯-7-基）乙酰胺
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关于此项目
经验公式（希尔记法）:
C22H25NO6
化学文摘社编号:
分子量:
399.44
EC Number:
200-598-5
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
2228813
MDL number:
impurities
≤3% water, ≤10% ethyl acetate + H2O
InChI key
IAKHMKGGTNLKSZ-INIZCTEOSA-N
InChI
1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
SMILES string
COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NC(C)=O
biological source
plant
assay
≥96.0% (HPLC)
form
fine crystals
mp
150-160 °C (dec.) (lit.)
solubility
water: soluble
Gene Information
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Other Notes
Binds specifically with tubulin thus interfering with microtubule organization.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Muta. 1B
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
P. Dustin
Microtubles, 11-11 (1978)
Romeo Romagnoli et al.
Journal of medicinal chemistry, 56(6), 2606-2618 (2013-03-01)
Two new series of inhibitors of tubulin polymerization based on the 2-(alkoxycarbonyl)-3-(3',4',5'-trimethoxyanilino)benzo[b]thiophene and thieno[2,3-b]pyridine molecular skeletons were synthesized and evaluated for antiproliferative activity on a panel of cancer cell lines, inhibition of tubulin polymerization, cell cycle effects, and in vivo
Liliya V Frolova et al.
Journal of medicinal chemistry, 56(17), 6886-6900 (2013-08-10)
We developed synthetic chemistry to access the marine alkaloid rigidins and over 40 synthetic analogues based on the 7-deazaxanthine, 7-deazaadenine, 7-deazapurine, and 7-deazahypoxanthine skeletons. Analogues based on the 7-deazahypoxanthine skeleton exhibited nanomolar potencies against cell lines representing cancers with dismal
Rimi Chakrabarti et al.
PloS one, 8(3), e57302-e57302 (2013-03-19)
Curcumin has been widely investigated for its myriad cellular effects resulting in reduced proliferation of various eukaryotic cells including cancer cells and the human malaria parasite Plasmodium falciparum. Studies with human cancer cell lines HT-29, Caco-2, and MCF-7 suggest that
Yan Lu et al.
Pharmaceutical research, 29(11), 2943-2971 (2012-07-21)
Tubulin dynamics is a promising target for new chemotherapeutic agents. The colchicine binding site is one of the most important pockets for potential tubulin polymerization destabilizers. Colchicine binding site inhibitors (CBSI) exert their biological effects by inhibiting tubulin assembly and
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