27696
米法斯丁
≥96% (HPLC)
别名:
ML-236B, 康帕丁
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关于此项目
经验公式（希尔记法）:
C23H34O5
化学文摘社编号:
分子量:
390.51
PubChem Substance ID:
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
1269441
MDL number:
assay
≥96% (HPLC)
mp
151-153 °C
antibiotic activity spectrum
fungi
mode of action
enzyme | inhibits
storage temp.
2-8°C
SMILES string
[H][C@]12[C@H](CCC=C1C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)OC(=O)[C@@H](C)CC
InChI
1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1
InChI key
AJLFOPYRIVGYMJ-INTXDZFKSA-N
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General description
Chemical structure: statin
Other Notes
Potent inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase, HMG-CoA reductase; Used e.g. in culturing compactin-resistant cell lines overaccumulating HMG-CoA reductase
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity.
A Endo et al.
FEBS letters, 72(2), 323-326 (1976-12-31)
Ml Pinzón-Daza et al.
British journal of pharmacology, 167(7), 1431-1447 (2012-07-14)
The passage of drugs across the blood-brain barrier (BBB) limits the efficacy of chemotherapy in brain tumours. For instance, the anticancer drug doxorubicin, which is effective against glioblastoma in vitro, has poor efficacy in vivo, because it is extruded by
Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase.
M S Brown et al.
The Journal of biological chemistry, 253(4), 1121-1128 (1978-02-25)
C E Nakamura et al.
Biochemistry, 24(6), 1364-1376 (1985-03-12)
The sodium salts of compactin (1) and trans-6-[2-(2,4- dichloro-6-hydroxyphenyl)ethyl]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran- 2-one (3) are inhibitors of yeast beta-hydroxy-beta-methylglutaryl coenzyme A (HMG-CoA) reductase. The dissociation constants are 0.24 X 10(-9) and 0.28 X 10(-9) M, respectively. Similar values have been reported for HMG-CoA
Yiwei Zhao et al.
The Journal of investigative dermatology, 131(5), 1045-1052 (2011-03-11)
Pachyonychia congenita (PC) is a keratinizing disorder predominantly caused by mutations in keratin 6a (K6a) (∼50% of cases) or K6b, K16, or K17. One means of treating PC is identification of small-molecule inhibitors of PC-related keratins. Here, we cloned the
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