29222
Thio-H
别名:
2-Amino-5-(5-phenyl-2-thienyl)phenol-N,N,O-triacetic acid tricesium salt
表单
solid
荧光
λex 332 nm; λem 500 nm in 0.1 M Tris pH 8.0, 10 mM Ca2+
SMILES字符串
[Cs+].[Cs+].[Cs+].[O-]C(=O)COc1cc(ccc1N(CC([O-])=O)CC([O-])=O)-c2ccc(s2)-c3ccccc3
InChI
1S/C22H19NO7S.3Cs/c24-20(25)11-23(12-21(26)27)16-7-6-15(10-17(16)30-13-22(28)29)19-9-8-18(31-19)14-4-2-1-3-5-14;;;/h1-10H,11-13H2,(H,24,25)(H,26,27)(H,28,29);;;/q;3*+1/p-3
InChI key
GBQDXALAYDCKJB-UHFFFAOYSA-K
特点和优势
This is a new Calcium indicator with promising properties which provide an excellent addition to fluorescent Ca2+/Mg2+ indicators available already. It is a low-affinity Ca2+-indicators (Kd ca 55 μM). Such indicators are useful for determination of Ca2+ in intracellular compartments [or for monitoring steep increases in intracellular concentration of Ca2+ .
Compared to wellknown low-affinity Ca2+ indicators Thio-H is about three times brighter. This is based on strong molar absorption as well as high quantum yields. High fluorescent output allows low indicator concentrations to be used, which decreases the cation buffering effects of indicator. The indicator offers the interesting property of being both excitation and emission rationable, thus ratiomeric measurements are possible both in excitations as emission mode. Further spectroscopic data (0.1 M Tris, pH 8.0): low [Ca2+], Exc.max. 362 nm, Em.max. 500 nm; high [Ca2+], Exc.max. 332 nm, Em.max. 500 nm
Compared to wellknown low-affinity Ca2+ indicators Thio-H is about three times brighter. This is based on strong molar absorption as well as high quantum yields. High fluorescent output allows low indicator concentrations to be used, which decreases the cation buffering effects of indicator. The indicator offers the interesting property of being both excitation and emission rationable, thus ratiomeric measurements are possible both in excitations as emission mode. Further spectroscopic data (0.1 M Tris, pH 8.0): low [Ca2+], Exc.max. 362 nm, Em.max. 500 nm; high [Ca2+], Exc.max. 332 nm, Em.max. 500 nm
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
其他说明
Intracellular, ratiomeric, fluorescent Ca2+/Mg2+ indicator with high brightness
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
E. Cielen et al. (N. Boens)
J. Chem. Soc. Perkin Trans. II, 1197-1197 (2002)
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