29222
Thio-H
别名:
2-Amino-5-(5-phenyl-2-thienyl)phenol-N,N,O-triacetic acid tricesium salt
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C22H16Cs3NO7S
分子量:
837.15
PubChem Substance ID:
UNSPSC Code:
12352202
Beilstein/REAXYS Number:
9244017
MDL number:
SMILES string
[Cs+].[Cs+].[Cs+].[O-]C(=O)COc1cc(ccc1N(CC([O-])=O)CC([O-])=O)-c2ccc(s2)-c3ccccc3
InChI
1S/C22H19NO7S.3Cs/c24-20(25)11-23(12-21(26)27)16-7-6-15(10-17(16)30-13-22(28)29)19-9-8-18(31-19)14-4-2-1-3-5-14;;;/h1-10H,11-13H2,(H,24,25)(H,26,27)(H,28,29);;;/q;3*+1/p-3
InChI key
GBQDXALAYDCKJB-UHFFFAOYSA-K
form
solid
fluorescence
λex 332 nm; λem 500 nm in 0.1 M Tris pH 8.0, 10 mM Ca2+
Features and Benefits
This is a new Calcium indicator with promising properties which provide an excellent addition to fluorescent Ca2+/Mg2+ indicators available already. It is a low-affinity Ca2+-indicators (Kd ca 55 μM). Such indicators are useful for determination of Ca2+ in intracellular compartments [or for monitoring steep increases in intracellular concentration of Ca2+ .
Compared to wellknown low-affinity Ca2+ indicators Thio-H is about three times brighter. This is based on strong molar absorption as well as high quantum yields. High fluorescent output allows low indicator concentrations to be used, which decreases the cation buffering effects of indicator. The indicator offers the interesting property of being both excitation and emission rationable, thus ratiomeric measurements are possible both in excitations as emission mode. Further spectroscopic data (0.1 M Tris, pH 8.0): low [Ca2+], Exc.max. 362 nm, Em.max. 500 nm; high [Ca2+], Exc.max. 332 nm, Em.max. 500 nm
Compared to wellknown low-affinity Ca2+ indicators Thio-H is about three times brighter. This is based on strong molar absorption as well as high quantum yields. High fluorescent output allows low indicator concentrations to be used, which decreases the cation buffering effects of indicator. The indicator offers the interesting property of being both excitation and emission rationable, thus ratiomeric measurements are possible both in excitations as emission mode. Further spectroscopic data (0.1 M Tris, pH 8.0): low [Ca2+], Exc.max. 362 nm, Em.max. 500 nm; high [Ca2+], Exc.max. 332 nm, Em.max. 500 nm
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Other Notes
Intracellular, ratiomeric, fluorescent Ca2+/Mg2+ indicator with high brightness
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
E. Cielen et al. (N. Boens)
J. Chem. Soc. Perkin Trans. II, 1197-1197 (2002)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持