30873
大黄酸
analytical standard
别名:
1,8-二羟基-3-羧基蒽醌, 4,5-二羟基蒽醌-2-羧酸, 9,10-二氢-4,5-二羟基-9,10-二氧代-2-蒽羧酸, 大黄苷, 大黄酸, 山扁豆酸, 柯嗪3-羧酸
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关于此项目
经验公式（希尔记法）:
C15H8O6
化学文摘社编号:
分子量:
284.22
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
EC Number:
207-521-4
Beilstein/REAXYS Number:
2222155
MDL number:
InChI
1S/C15H8O6/c16-9-3-1-2-7-11(9)14(19)12-8(13(7)18)4-6(15(20)21)5-10(12)17/h1-5,16-17H,(H,20,21)
SMILES string
OC(=O)c1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1
InChI key
FCDLCPWAQCPTKC-UHFFFAOYSA-N
grade
analytical standard
assay
≥95.0% (HPLC)
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
impurities
≤5.0% water
mp
≥300 °C (lit.)
application(s)
food and beverages
format
neat
Quality Level
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General description
Rhein is an active component of rhubarb (Rheum officinale), a medicinal herb in traditional Chinese medicine (TCM). It is known to exhibit antibacterial and anti-inflammatory activities.
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Rhein may be used as an analytical reference standard for the determination of the analyte in rat plasma and rhubarb roots, dock flowers and senna leaves by column-switching high-performance liquid chromatography and normal-phase high performance liquid chromatography, respectively.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 2
Simultaneous determination of baicalin, rhein and berberine in rat plasma by column-switching high-performance liquid chromatography.
Yi L, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 838(1), 50-55 (2006)
Determination of anthraquinones in rhubarb roots, dock flowers and senna leaves by normal-phase high performance liquid chromatography.
Djozan DJ and Assadi Y
Talanta, 42(6), 861-865 (1995)
Rhein reverses Klotho repression via promoter demethylation and protects against kidney and bone injuries in mice with chronic kidney disease.
Zhang Q, et al.
Kidney International, 91(1), 144-156 (2017)
Rhein protects against acetaminophen-induced hepatic and renal toxicity.
Zhao YL, et al.
Food And Chemical Toxicology, 49(8), 1705-1710 (2011)
Baoen Chen et al.
Journal of the American Chemical Society, 134(43), 17963-17971 (2012-10-11)
The direct nucleic acid repair dioxygenase FTO is an enzyme that demethylates N(6)-methyladenosine (m(6)A) residues in mRNA in vitro and inside cells. FTO is the first RNA demethylase discovered that also serves a major regulatory function in mammals. Together with
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