30925
虫草素
≥98.0% (HPLC)
别名:
3′-脱氧腺苷
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关于此项目
经验公式（希尔记法）:
C10H13N5O3
化学文摘社编号:
分子量:
251.24
EC Number:
200-791-4
UNSPSC Code:
12352203
PubChem Substance ID:
Beilstein/REAXYS Number:
35194
MDL number:
InChI key
OFEZSBMBBKLLBJ-BAJZRUMYSA-N
InChI
1S/C10H13N5O3/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(17)1-5(2-16)18-10/h3-6,10,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,10+/m0/s1
SMILES string
Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)C[C@H]3O
assay
≥98.0% (HPLC)
mp
225-229 °C
antibiotic activity spectrum
fungi
mode of action
DNA synthesis | interferes, enzyme | inhibits
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General description
Chemical structure: nucleoside
Biochem/physiol Actions
虫草素是一种腺苷类似物，易于转化为5′-三磷酸虫草素；可用于RNA的3′-端标记。
Other Notes
Starting material for the synthesis of cordycepin triphosphate, an inhibitor of replicative synthesis
法规信息
新产品
此项目有
Suman K Vodnala et al.
Journal of medicinal chemistry, 56(24), 9861-9873 (2013-11-29)
Novel methods for treatment of African trypanosomiasis, caused by infection with Trypanosoma brucei are needed. Cordycepin (3'-deoxyadenosine, 1a) is a powerful trypanocidal compound in vitro but is ineffective in vivo because of rapid metabolic degradation by adenosine deaminase (ADA). We
Hong Jue Lee et al.
Investigational new drugs, 30(5), 1917-1925 (2012-07-24)
The fungal drug cordycepin (3-deoxyadenosine) is known to exert anti-tumor activities, preferentially by interfering with RNA synthesis. We have investigated the effect of cordycepin on human breast epithelial cell lines, ranging from non-malignant MCF10A cells to highly de-differentiated MDA-MB-435 cancer
Ying-Yi Chen et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 19(8-9), 768-778 (2012-04-03)
Cancer metastasis is a primary cause of cancer death. Antrodia cinnamomea (A. cinnamomea), a medicinal mushroom in Taiwan, has been shown antioxidant and anticancer activities. In this study, we first observed that ethanol extract of fruiting bodies of A. cinnamomea
Yukako Chiba et al.
Plant & cell physiology, 54(2), 180-194 (2012-12-12)
Control of mRNA half-life is a powerful strategy to adjust individual mRNA levels to various stress conditions, because the mRNA degradation rate controls not only the steady-state mRNA level but also the transition speed of mRNA levels. Here, we analyzed
Himal Luitel et al.
Medicina (Kaunas, Lithuania), 56(3) (2020-03-20)
Background and objectives: Pulmonary hypertension (PH) is characterized by the vasoconstriction and abnormally proliferative vascular cells. The available allopathic treatment options for PH are still not able to cure the disease. Alternative medicine is becoming popular and drawing the attention
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