32570
N,N-二乙基-3-甲基苯甲酰胺
purum, ≥95.0% (GC)
别名:
N,N-二乙基-间甲苯酰胺, DEET, 间甲苯酸二乙胺
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线性分子式:
CH3C6H4CON(C2H5)2
化学文摘社编号:
分子量:
191.27
EC Number:
205-149-7
UNSPSC Code:
12352100
PubChem Substance ID:
Beilstein/REAXYS Number:
2046711
MDL number:
vapor density
6.7 (vs air)
vapor pressure
<0.01 mmHg ( 25 °C)
grade
purum
assay
≥95.0% (GC)
refractive index
n20/D 1.523
bp
111 °C/1 mmHg, 160 °C/19 mmHg (lit.)
density
0.998 g/mL at 20 °C (lit.)
SMILES string
CCN(CC)C(=O)c1cccc(C)c1
InChI
1S/C12H17NO/c1-4-13(5-2)12(14)11-8-6-7-10(3)9-11/h6-9H,4-5H2,1-3H3
InChI key
MMOXZBCLCQITDF-UHFFFAOYSA-N
General description
N,N-Diethyl-3-methylbenzamide (DEET) is an all-purpose topical insect repellent and its pharmacokinetics, formulation and safety aspects were discussed. DEET was reported to kill cercariae of Schistosoma mansoni in vitro. DEET is a potent cercariacide and an effective agent at preventing cercarial penetration into treated mouse tail skin.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Skin Irrit. 2
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
203.0 °F - closed cup
flash_point_c
95 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
W E Secor et al.
The American journal of tropical medicine and hygiene, 60(6), 1061-1062 (1999-07-14)
N,N-diethyl-3-methylbenzamide (DEET) has recently been reported to kill cercariae of Schistosoma mansoni in vitro. In addition, it blocked cercarial entry into mouse tail skin. We confirmed these results and compared the efficacy of DEET to a second insect repellent, 1-(3-Cyclohexen-1-yl-carbonyl)-2-methylpiperidine
Daniel L Sudakin et al.
Journal of toxicology. Clinical toxicology, 41(6), 831-839 (2003-12-18)
The emergence of West Nile Virus (WNV) in North America has resulted in increased public awareness and utilization of insect repellents containing N,N-diethyl-m-toluamide (DEET) in the prevention of mosquito-borne disease. Regulatory reassessments in North American countries have recently been completed
T G Osimitz et al.
Journal of toxicology. Clinical toxicology, 35(5), 435-441 (1997-01-01)
N,N-Diethyl-m-toluamide, an effective tick repellent, when applied to the skin, is the major component of essentially all of the products marketed for this purpose. It is used by about 30% of the US population, and by 23-29% of children in
P J Robbins et al.
Journal of toxicology and environmental health, 18(4), 503-525 (1986-01-01)
A review of the biodistribution and toxicity of the insect repellent N,N-diethyl-m-toluamide (DEET) is presented. Workers using repellent containing this compound may be exposed to greater than 442 g in 6 mo. In human studies, variable penetration into the skin
Pinky Kain et al.
Nature, 502(7472), 507-512 (2013-10-04)
There are major impediments to finding improved DEET alternatives because the receptors causing olfactory repellency are unknown, and new chemicals require exorbitant costs to determine safety for human use. Here we identify DEET-sensitive neurons in a pit-like structure in the
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