产品名称
阿扎哌醇, VETRANAL®, analytical standard
SMILES string
OC(CCCN1CCN(CC1)c2ccccn2)c3ccc(F)cc3
InChI
1S/C19H24FN3O/c20-17-8-6-16(7-9-17)18(24)4-3-11-22-12-14-23(15-13-22)19-5-1-2-10-21-19/h1-2,5-10,18,24H,3-4,11-15H2
InChI key
LVXYAFNPMXCRJI-UHFFFAOYSA-N
grade
analytical standard
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
Quality Level
Application
Azaperol may be used as an analytical reference standard for the determination of the analyte in:
- Pig tissues by liquid chromatography–tandem mass spectrometry (LC-MS/MS).
- Egg, fish and meat samples by high-resolution liquid chromatography coupled to time-of-flight mass spectrometry (HRLC-TOF-MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
General description
Azaperol is one of the major metabolites of azaperone which is used as a tranquilizer.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
M L Olmos-Carmona et al.
Journal of chromatography. B, Biomedical sciences and applications, 734(1), 113-120 (1999-11-26)
A method for analysis of veterinary tranquillizers in urine using gas chromatography-mass spectrometry (GC-MS) is described. Detection limits are 5 microg/l for ketamine, azaperone and the phenothiazines (chlor-, aceto- and propionylpromazine), 10 microg/l for haloperidol, 20 microg/l for xylazine and
J C Jaen et al.
Journal of medicinal chemistry, 36(24), 3929-3936 (1993-11-26)
The enantiomers of reduced haloperidol (3a), azaperol (3b), and the related compound BMY-14802 (3c) were prepared in high optical purity. The affinity of these compounds for dopamine D2 and D3 receptors, and sigma S1 and S2 sites was determined in
Multi-residue screening of veterinary drugs in egg, fish and meat using high-resolution liquid chromatography accurate mass time-of-flight mass spectrometry.
Peters RJB, et al.
Journal of Chromatography A, 1216(46), 8206-8216 (2009)
D Fluchard et al.
Journal of chromatography. B, Biomedical sciences and applications, 744(1), 139-147 (2000-09-14)
A quick, simple method for quantifying carazolol, azaperol and azaperone is described. Liquid extraction was followed by a clean-up on an Oasis SPE cartridge. The analytes were separated by HPLC and analysed by MS-MS with atmospheric pressure chemical ionisation in
L A Adam
Journal of AOAC International, 82(4), 815-824 (1999-08-13)
The method described confirms the use of the tranquilizer azaperone by detecting the parent compound and the metabolically reduced form, azaperol. Both are confirmed in swine liver at a target concentration of 10 ppb by gas chromatography/mass spectrometry (GC/MS) with
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