grade
analytical standard
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
clinical
forensics and toxicology
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
SMILES string
CNC(=O)C[C@@H](N)C(=O)N[C@@H](C(=O)N[C@H]1C2SC(C)(C)C(N2C1=O)C(O)=O)c3ccc(O)cc3
InChI
1S/C21H27N5O7S/c1-21(2)15(20(32)33)26-18(31)14(19(26)34-21)25-17(30)13(9-4-6-10(27)7-5-9)24-16(29)11(22)8-12(28)23-3/h4-7,11,13-15,19,27H,8,22H2,1-3H3,(H,23,28)(H,24,29)(H,25,30)(H,32,33)/t11-,13-,14-,15+,19-/m1/s1
InChI key
BHELIUBJHYAEDK-OAIUPTLZSA-N
General description
Aspoxicillin is classified under the β-lactam family of antibiotics.
Application
Aspoxicillin may be used as an analytical reference standard for the determination of the analyte in:
- Meat samples by ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS).
- Fish, shrimp and eel by LC coupled to quadrupole high resolution MS.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
涉药品监管产品
此项目有
J Geyer et al.
Arzneimittel-Forschung, 38(11), 1635-1639 (1988-11-01)
The pharmacokinetics of aspoxicillin [2S,5R,6R)-6-[(2R)-2-[(2R)-2-amino-3-(methylcarbamoyl)propionam ido]-2- (p-hydroxyphenyl)acetamido]penicillanic acid) in 10 subjects with normal kidney function and in 20 patients suffering from impaired renal function were examined after an i.v. short-term infusion of 4 g for a period of 20 min.
T Oshida et al.
The Journal of antimicrobial chemotherapy, 26(1), 29-38 (1990-07-01)
Aspoxicillin, a newly developed acylureido-penicillin with a long half-life in mouse serum of 55 min, induced postantibiotic effects (PAEs) against Staphylococcus aureus Smith of 1.7 h in vitro and 5.2 h in vivo in a thigh infection model in neutropenic
K Deguchi et al.
The Japanese journal of antibiotics, 46(4), 295-309 (1993-04-01)
The Antimicrobial activity of aspoxicillin (ASPC) in terms of minimum inhibitory concentration (MICs) was compared with those of other penicillin antibiotics (PCs) against clinical isolates sent to us from medical institutions throughout Japan in 1988, 1990 and 1992 and strains