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Merck
CN

34202

非那雄胺

VETRANAL®, analytical standard

别名:

N-叔丁基-3-氧代-4-氮杂-5α-雄甾-1-烯-17β-甲酰胺, MK-906, N-(2-甲基-2-丙基)-3-氧代-4-氮杂-5α-雄甾-1-烯-17β-甲酰胺

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经验公式(希尔记法):
C23H36N2O2
化学文摘社编号:
分子量:
372.54
UNSPSC Code:
41116107
PubChem Substance ID:
MDL number:
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InChI

1S/C23H36N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h11,13-18H,6-10,12H2,1-5H3,(H,24,26)(H,25,27)/t14-,15-,16-,17+,18+,22-,23+/m0/s1

SMILES string

[H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](C(=O)NC(C)(C)C)[C@@]4(C)CC[C@]3([H])[C@@]1(C)C=CC(=O)N2

InChI key

DBEPLOCGEIEOCV-WSBQPABSSA-N

grade

analytical standard

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

Quality Level

Gene Information

human ... SRD5A2(6716)

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Application

Finasteride may be used as an analytical reference standard for the determination of the analyte in biological fluids and pharmaceutical formulations by high performance liquid chromatography (HPLC) method.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

选择性 5α-还原酶抑制剂;抗雄激素。

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazardExclamation mark

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Determination of finasteride in tablets by high performance liquid chromatography.
Basavaiah K and Somashekar BC
Journal of Chemistry, 4(1), 109-116 (2007)
Mary K Samplaski et al.
Fertility and sterility, 100(6), 1542-1546 (2013-09-10)
To determine the degree of improvement in semen parameters after finasteride discontinuation. A prospective database of men presenting for a fertility evaluation was analyzed for semen and hormone parameters before and after discontinuation of finasteride. A male infertility specialty clinic.
Asad Umar et al.
Nature reviews. Cancer, 12(12), 835-848 (2012-11-16)
Prevention of cancer remains the most promising strategy for reducing both its incidence and the mortality due to this disease. For more than four decades, findings from epidemiology, basic research and clinical trials have informed the development of lifestyle and
Marian L Neuhouser et al.
Cancer prevention research (Philadelphia, Pa.), 6(2), 91-99 (2013-01-15)
The role of the insulin-like growth factor (IGF) axis and whether IGFs interact with androgen-suppressing agents in relation to prostate carcinogenesis is unclear. This nested case-control study (n = 1,652 cases/1,543 controls) examined whether serum IGF1, IGF2, IGFBP2, IGFBP3, and
High-performance liquid chromatographic determination of finasteride in human plasma using direct injection with column switching.
Takano T and Hata S
Journal of Chromatography. B, Biomedical Sciences and Applications, 676(1), 141-146 (1996)

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