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Merck
CN

36777

地丹诺辛

≥95% (HPLC)

别名:

ddI, ddIno

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经验公式（希尔记法）:
C10H12N4O3
化学文摘社编号:
69655-05-6
分子量:
236.23
UNSPSC Code:
12161700
Beilstein/REAXYS Number:
3619529
MDL number:
MFCD00077728

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assay

≥95% (HPLC)

impurities

≤1% water

mp

193-195 °C

application(s)

agriculture
environmental

storage temp.

2-8°C

SMILES string

OC[C@@H]1CC[C@@H](O1)n2cnc3C(=O)NC=Nc23

InChI

1S/C10H12N4O3/c15-3-6-1-2-7(17-6)14-5-13-8-9(14)11-4-12-10(8)16/h4-7,15H,1-3H2,(H,11,12,16)/t6-,7+/m0/s1

InChI key

BXZVVICBKDXVGW-NKWVEPMBSA-N

Other Notes

实验用抗逆转录病毒剂

法规信息

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J E Dahlberg et al.
Proceedings of the National Academy of Sciences of the United States of America, 84(8), 2469-2473 (1987-04-01)
Certain dideoxynucleosides have been shown to markedly inhibit the infectivity of human T-lymphotropic virus type III/lymphadenopathy-associated virus, the causative agent of acquired immunodeficiency syndrome (AIDS). Our present studies demonstrate that these drugs are broad spectrum antiretroviral agents capable of inhibiting
Initial studies on the cellular pharmacology of 2',3'-dideoxyinosine, an inhibitor of HIV infectivity.
G Ahluwalia et al.
Biochemical pharmacology, 36(22), 3797-3800 (1987-11-15)
Nicolas Sluis-Cremer et al.
Antimicrobial agents and chemotherapy, 53(9), 3715-3719 (2009-07-15)
Although the approved nucleoside reverse transcriptase (RT) inhibitors (NRTI) are integral components of therapy for human immunodeficiency virus type 1 (HIV-1) infection, they can have significant limitations, including the selection of NRTI-resistant HIV-1 and cellular toxicity. Accordingly, there is a
H Mitsuya et al.
Proceedings of the National Academy of Sciences of the United States of America, 83(6), 1911-1915 (1986-03-01)
Human T-lymphotropic virus type III (HTLV-III)/lymphadenopathy-associated virus (LAV) is a a newly discovered lymphotropic retrovirus that is cytopathic for helper/inducer T cells in vitro. This virus is the etiologic agent of the acquired immunodeficiency syndrome and related diseases. In the

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850715P-500MG04061835231188
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850715P-1G04061835231157
850715P-200MG04061835231164
P3531-100MG04061834368106
P3531-500MG04061834368113

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